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    Tbx3 T-box 3 [ Mus musculus (house mouse) ]

    Gene ID: 21386, updated on 20-Jul-2021

    Summary

    Official Symbol
    Tbx3provided by MGI
    Official Full Name
    T-box 3provided by MGI
    Primary source
    MGI:MGI:98495
    See related
    Ensembl:ENSMUSG00000018604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D5Ertd189; D5Ertd189e
    Expression
    Biased expression in adrenal adult (RPKM 118.3), small intestine adult (RPKM 47.5) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tbx3 in Genome Data Viewer
    Location:
    5 F; 5 60.34 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (119808600..119822789)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (119670534..119684724)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (120120678..120134610)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene T-box 3, opposite strand 1 Neighboring gene predicted gene 16063 Neighboring gene enhancer eA upstream of Tbx3 Neighboring gene predicted gene 16064 Neighboring gene T-box 3, opposite strand 2 Neighboring gene predicted gene, 42017

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in anterior/posterior axis specification, embryo ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within atrioventricular bundle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in atrioventricular canal development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in atrioventricular canal morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac chamber development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cardiac epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac jelly development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac muscle cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell aging ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within embryonic digit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic forelimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endocardial cushion formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female genitalia development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in follicle-stimulating hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within forelimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in heart looping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within limbic system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in luteinizing hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in male genitalia development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mammary gland development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mammary placode formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within mammary placode formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mesoderm morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell proliferation involved in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within roof of mouth development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within sinoatrial node cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sinoatrial node cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within smooth muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within specification of animal organ position IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ureteric peristalsis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within ventricular septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    T-box transcription factor TBX3
    Names
    T-box protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011535.3NP_035665.2  T-box transcription factor TBX3 isoform 1

      See identical proteins and their annotated locations for NP_035665.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA543734, AK052453, AK145436, BB054411, BB694449, BB728182, CJ216213
      Consensus CDS
      CCDS19613.1
      UniProtKB/Swiss-Prot
      P70324
      UniProtKB/TrEMBL
      Q3ULL3
      Related
      ENSMUSP00000018748.9, ENSMUST00000018748.9
      Conserved Domains (2) summary
      pfam00907
      Location:105305
      T-box
      pfam12598
      Location:323402
      TBX; T-box transcription factor
    2. NM_198052.2NP_932169.1  T-box transcription factor TBX3 isoform 2

      See identical proteins and their annotated locations for NP_932169.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AA543734, BB054411, BB694449, BB728182, BC096551, CJ216213
      Consensus CDS
      CCDS19614.1
      UniProtKB/TrEMBL
      Q4VA43
      Related
      ENSMUSP00000112519.2, ENSMUST00000121021.8
      Conserved Domains (2) summary
      pfam12598
      Location:303391
      TBX; T-box transcription factor
      cd00182
      Location:102287
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      119808600..119822789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530276.5XP_006530339.1  T-box transcription factor TBX3 isoform X1

      See identical proteins and their annotated locations for XP_006530339.1

      UniProtKB/Swiss-Prot
      P70324
      Conserved Domains (2) summary
      pfam00907
      Location:105305
      T-box
      pfam12598
      Location:323402
      TBX; T-box transcription factor
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