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    Asl argininosuccinate lyase [ Mus musculus (house mouse) ]

    Gene ID: 109900, updated on 23-Jun-2021

    Summary

    Official Symbol
    Aslprovided by MGI
    Official Full Name
    argininosuccinate lyaseprovided by MGI
    Primary source
    MGI:MGI:88084
    See related
    Ensembl:ENSMUSG00000025533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ASAL; 2510006M18Rik
    Expression
    Biased expression in liver adult (RPKM 129.2), kidney adult (RPKM 88.2) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Asl in Genome Data Viewer
    Location:
    5 G1.3; 5 68.37 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (130040099..130053222, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (130011258..130024381, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (130487373..130500201, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene nuclear protein transcriptional regulator 1 like Neighboring gene vitamin K epoxide reductase complex, subunit 1-like 1 Neighboring gene glucuronidase, beta Neighboring gene predicted gene, 40334 Neighboring gene calcitonin gene-related peptide-receptor component protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables argininosuccinate lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables argininosuccinate lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell body fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    argininosuccinate lyase
    Names
    arginosuccinase
    NP_598529.1
    XP_006504404.1
    XP_036020620.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133768.5NP_598529.1  argininosuccinate lyase

      See identical proteins and their annotated locations for NP_598529.1

      Status: VALIDATED

      Source sequence(s)
      AI325988, AK140160, BY770404
      Consensus CDS
      CCDS51655.1
      UniProtKB/Swiss-Prot
      Q91YI0
      Related
      ENSMUSP00000124274.2, ENSMUST00000161094.8
      Conserved Domains (1) summary
      cd01359
      Location:27459
      Argininosuccinate_lyase; Argininosuccinate lyase (argininosuccinase, ASAL)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      130040099..130053222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164727.1XP_036020620.1  argininosuccinate lyase isoform X2

      Related
      ENSMUSP00000125143.3, ENSMUST00000159096.8
      Conserved Domains (1) summary
      cd01359
      Location:1230
      Argininosuccinate_lyase; Argininosuccinate lyase (argininosuccinase, ASAL)
    2. XM_006504341.5XP_006504404.1  argininosuccinate lyase isoform X1

      See identical proteins and their annotated locations for XP_006504404.1

      UniProtKB/Swiss-Prot
      Q91YI0
      Related
      ENSMUSP00000124579.2, ENSMUST00000160129.8
      Conserved Domains (1) summary
      cd01359
      Location:27459
      Argininosuccinate_lyase; Argininosuccinate lyase (argininosuccinase, ASAL)
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