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    Naca nascent polypeptide-associated complex alpha polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 17938, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nacaprovided by MGI
    Official Full Name
    nascent polypeptide-associated complex alpha polypeptideprovided by MGI
    Primary source
    MGI:MGI:106095
    See related
    Ensembl:ENSMUSG00000061315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sk; skNAC; Gm1878; D12Mgi4; AL022831; AL024382; mKIAA0363
    Expression
    Ubiquitous expression in heart adult (RPKM 34.3), CNS E11.5 (RPKM 24.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Naca in Genome Data Viewer
    Location:
    10; 10 D3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127869144..127884506)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128035346..128048637)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127472402..127485693)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein D2 pseudogene Neighboring gene DNA primase, p49 subunit Neighboring gene prostaglandin E synthase 3 Neighboring gene predicted gene, 47438 Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables TBP-class protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cardiac ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart trabecula morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within myoblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of striated muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription from RNA polymerase II promoter involved in heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell proliferation involved in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of skeletal muscle tissue growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription from RNA polymerase II promoter involved in heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in skeletal muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nascent polypeptide-associated complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nascent polypeptide-associated complex subunit alpha
    Names
    alpha-NAC, muscle-specific form
    alpha-NAC/1.9.2
    nascent polypeptide-associated complex alpha subunit
    nascent polypeptide-associated complex subunit alpha, muscle-specific form
    NP_001106670.1
    NP_001269905.1
    NP_038636.2
    XP_036011564.1
    XP_036011565.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113199.1NP_001106670.1  nascent polypeptide-associated complex subunit alpha isoform a

      See identical proteins and their annotated locations for NP_001106670.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC131120, CN840834, U48364
      Consensus CDS
      CCDS48723.1
      UniProtKB/Swiss-Prot
      P70670
      Related
      ENSMUSP00000089680.6, ENSMUST00000092048.13
      Conserved Domains (3) summary
      PHA03247
      Location:10571559
      PHA03247; large tegument protein UL36; Provisional
      cd14415
      Location:21412186
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:20562103
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
    2. NM_001282976.1NP_001269905.1  nascent polypeptide-associated complex subunit alpha isoform b

      See identical proteins and their annotated locations for NP_001269905.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional segment in the 5' UTR and lacks an in-frame large exon in the coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a. Variants 2 and 3 encode the same isoform b.
      Source sequence(s)
      AC131120, BC083340, CX236470, U22151
      Consensus CDS
      CCDS24258.1
      UniProtKB/Swiss-Prot
      Q60817
      Conserved Domains (2) summary
      cd14415
      Location:169214
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:84131
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
    3. NM_013608.3NP_038636.2  nascent polypeptide-associated complex subunit alpha isoform b

      See identical proteins and their annotated locations for NP_038636.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal in-frame large exon in the coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a. Variants 2 and 3 encode the same isoform b.
      Source sequence(s)
      BC083340, CN840834, U48364
      Consensus CDS
      CCDS24258.1
      UniProtKB/Swiss-Prot
      P70670, Q60817
      Related
      ENSMUSP00000073532.8, ENSMUST00000073868.9
      Conserved Domains (2) summary
      cd14415
      Location:169214
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:84131
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127869144..127884506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155672.1XP_036011565.1  nascent polypeptide-associated complex subunit alpha isoform X2

      Conserved Domains (2) summary
      cd14415
      Location:169214
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:84131
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
    2. XM_036155671.1XP_036011564.1  nascent polypeptide-associated complex subunit alpha isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:10571559
      PHA03247; large tegument protein UL36; Provisional
      cd14415
      Location:21412186
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:20562103
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
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