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    Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 [ Mus musculus (house mouse) ]

    Gene ID: 27400, updated on 23-Jun-2021

    Summary

    Official Symbol
    Hsd17b6provided by MGI
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 6provided by MGI
    Primary source
    MGI:MGI:1351670
    See related
    Ensembl:ENSMUSG00000025396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rdh; Rdh8; Hsd17b; Hsd17b9; 17betaHS; 17betaHSD9
    Expression
    Biased expression in liver adult (RPKM 99.6), duodenum adult (RPKM 16.6) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hsd17b6 in Genome Data Viewer
    Location:
    10; 10 D3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127826800..127843517, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127990931..128007648, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127427992..127444564, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23996 Neighboring gene ring finger protein 181 pseudogene Neighboring gene small nuclear ribonucleoprotein D2 pseudogene Neighboring gene DNA primase, p49 subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in brexanolone catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    17-beta-hydroxysteroid dehydrogenase type 6
    Names
    17-beta-HSD 6
    17-beta-HSD6
    17-beta-HSD9
    3-alpha->beta-HSE
    3-alpha->beta-hydroxysteroid epimerase
    hydroxysteroid (17-beta) dehydrogenase 9
    oxidative 3-alpha hydroxysteroid dehydrogenase
    NP_001346306.1
    NP_038814.1
    XP_011241766.1
    XP_011241767.1
    XP_011241769.1
    XP_011241770.1
    XP_030100965.1
    XP_030100966.1
    XP_030100967.1
    XP_030100968.1
    XP_030100969.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359377.1NP_001346306.1  17-beta-hydroxysteroid dehydrogenase type 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC131120, AK008212
      Consensus CDS
      CCDS24257.1
      Related
      ENSMUSP00000151661.2, ENSMUST00000219183.2
      Conserved Domains (1) summary
      cl21454
      Location:30306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. NM_013786.3NP_038814.1  17-beta-hydroxysteroid dehydrogenase type 6 precursor

      See identical proteins and their annotated locations for NP_038814.1

      Status: VALIDATED

      Source sequence(s)
      AC131120, AK008212
      Consensus CDS
      CCDS24257.1
      UniProtKB/Swiss-Prot
      Q9R092
      Related
      ENSMUSP00000151556.2, ENSMUST00000219447.2
      Conserved Domains (1) summary
      cl21454
      Location:30306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127826800..127843517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243465.3XP_011241767.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      See identical proteins and their annotated locations for XP_011241767.1

      UniProtKB/Swiss-Prot
      Q9R092
      Conserved Domains (1) summary
      cl21454
      Location:30306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_011243464.3XP_011241766.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      See identical proteins and their annotated locations for XP_011241766.1

      UniProtKB/Swiss-Prot
      Q9R092
      Conserved Domains (1) summary
      cl21454
      Location:30306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. XM_030245105.1XP_030100965.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:30306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. XM_030245108.1XP_030100968.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:30306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    5. XM_030245106.1XP_030100966.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:30306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    6. XM_030245107.1XP_030100967.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:30306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    7. XM_011243467.3XP_011241769.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      See identical proteins and their annotated locations for XP_011241769.1

      UniProtKB/Swiss-Prot
      Q9R092
      Conserved Domains (1) summary
      cl21454
      Location:30306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    8. XM_030245109.1XP_030100969.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:30262
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    9. XM_011243468.3XP_011241770.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:30262
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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