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    Grk6 G protein-coupled receptor kinase 6 [ Mus musculus (house mouse) ]

    Gene ID: 26385, updated on 23-Jun-2021

    Summary

    Official Symbol
    Grk6provided by MGI
    Official Full Name
    G protein-coupled receptor kinase 6provided by MGI
    Primary source
    MGI:MGI:1347078
    See related
    Ensembl:ENSMUSG00000074886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpr; Gprk6
    Expression
    Ubiquitous expression in spleen adult (RPKM 77.5), thymus adult (RPKM 59.5) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Grk6 in Genome Data Viewer
    Location:
    13 B1; 13 30.06 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55592865..55608740)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55445072..55460927)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55546695..55562288)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 34 (sodium phosphate), member 1 Neighboring gene profilin 3 Neighboring gene coagulation factor XII (Hageman factor) Neighboring gene microRNA 6943 Neighboring gene proline rich 7 (synaptic) Neighboring gene drebrin 1 Neighboring gene microRNA 6944

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables G protein-coupled receptor kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-adrenergic receptor kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in desensitization of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of anion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    G protein-coupled receptor kinase 6
    Names
    g protein-coupled receptor kinase GRK6
    NP_001033107.1
    NP_001106182.1
    NP_001272992.1
    NP_001272993.1
    NP_001272994.1
    NP_001272995.1
    NP_001364005.1
    NP_001364006.1
    NP_036068.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038018.5NP_001033107.1  G protein-coupled receptor kinase 6 isoform a

      See identical proteins and their annotated locations for NP_001033107.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK051405, AW048460, CT009762, Y15799
      UniProtKB/Swiss-Prot
      O70293
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. NM_001112711.2NP_001106182.1  G protein-coupled receptor kinase 6 isoform c

      See identical proteins and their annotated locations for NP_001106182.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK051405, AW048460, CT009762, Y15799
      Consensus CDS
      CCDS88457.1
      UniProtKB/Swiss-Prot
      O70293
      Related
      ENSMUSP00000152968.2, ENSMUST00000224118.2
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. NM_001286063.2NP_001272992.1  G protein-coupled receptor kinase 6 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK051405, AW048460, CT009762, Y15799
      UniProtKB/Swiss-Prot
      O70293
      UniProtKB/TrEMBL
      A0A286YDZ5
      Related
      ENSMUSP00000153623.2, ENSMUST00000224653.2
      Conserved Domains (3) summary
      smart00220
      Location:154416
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:153437
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:3147
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    4. NM_001286064.2NP_001272993.1  G protein-coupled receptor kinase 6 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
      Source sequence(s)
      AK051405, AW048460, CT009762, Y15799
      UniProtKB/Swiss-Prot
      O70293
      UniProtKB/TrEMBL
      A0A286YDA5
      Conserved Domains (3) summary
      smart00220
      Location:186443
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185464
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    5. NM_001286065.1NP_001272994.1  G protein-coupled receptor kinase 6 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the central coding region, and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (f) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK051405, AW048460, CT009762, Y15799
      Consensus CDS
      CCDS88458.1
      UniProtKB/Swiss-Prot
      O70293
      UniProtKB/TrEMBL
      A0A286YE10
      Related
      ENSMUSP00000153668.2, ENSMUST00000225925.2
      Conserved Domains (3) summary
      smart00220
      Location:186414
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:185435
      PKc_like; Protein Kinases, catalytic domain
    6. NM_001286066.2NP_001272995.1  G protein-coupled receptor kinase 6 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR, 3' UTR, and 3' coding region, and cause translation initiation from a downstream start codon. The encoded isoform (g) has a shorter N-terminus and a distinct and shorter C-terminus, compared to isoform a.
      Source sequence(s)
      CT009762
      UniProtKB/TrEMBL
      Q9EP84
      Conserved Domains (2) summary
      smart00220
      Location:1183
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1204
      PKc_like; Protein Kinases, catalytic domain
    7. NM_001377076.1NP_001364005.1  G protein-coupled receptor kinase 6 isoform h

      Status: VALIDATED

      Source sequence(s)
      CT009762
      Conserved Domains (2) summary
      cd05630
      Location:180464
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:30174
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    8. NM_001377077.1NP_001364006.1  G protein-coupled receptor kinase 6 isoform i

      Status: VALIDATED

      Source sequence(s)
      CT009762
      Conserved Domains (1) summary
      cl21453
      Location:1204
      PKc_like; Protein Kinases, catalytic domain
    9. NM_011938.5NP_036068.2  G protein-coupled receptor kinase 6 isoform b

      See identical proteins and their annotated locations for NP_036068.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      CT009762
      Consensus CDS
      CCDS36676.1
      UniProtKB/Swiss-Prot
      O70293
      UniProtKB/TrEMBL
      Q9EP84
      Related
      ENSMUSP00000097081.4, ENSMUST00000099482.5
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      55592865..55608740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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