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    Pvt1 Pvt1 oncogene [ Mus musculus (house mouse) ]

    Gene ID: 19296, updated on 26-Jul-2021

    Summary

    Official Symbol
    Pvt1provided by MGI
    Official Full Name
    Pvt1 oncogeneprovided by MGI
    Primary source
    MGI:MGI:97824
    See related
    Ensembl:ENSMUSG00000097039
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mis; Mlv; Pvt; Mis-1; Pvt-1; Mlvi-1; Ayu21-84Imeg; Gt(pU21)84Imeg
    Summary
    This gene produces a long non-coding RNA that has been identified as a candidate oncogene. In humans, increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Consistently, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. In mouse, this gene has also been found to be a potential regulator of cardiac hypertrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in cortex adult (RPKM 2.0), bladder adult (RPKM 1.5) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Pvt1 in Genome Data Viewer
    Location:
    15 D1; 15 26.24 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (61909835..62132064)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (62037986..62260215)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (61869542..62082530)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene origin of replication upstream of Myc Neighboring gene myelocytomatosis oncogene Neighboring gene predicted gene, 53890 Neighboring gene macroH2A.3 histone Neighboring gene predicted gene, 41333 Neighboring gene predicted gene, 22521

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

    Markers

    Homology

    Other Names

    • plasmacytoma variant translocation 1

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003368.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC126552, AK010708, AK043790, AK169445, BY473510
    2. NR_132746.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate first exon and lacks two internal exons compared to variant 1.
      Source sequence(s)
      AC126552, AK010708, AK020628, AK169445, BY473510
      Related
      ENSMUST00000181657.9
    3. NR_132747.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks internal exons and uses an alternate 3'-terminal exon compared to variant 1.
      Source sequence(s)
      AC126552, AI428930, AK013704, AK043252, AK043790

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      61909835..62132064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_011222.1: Suppressed sequence

      Description
      NM_011222.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
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