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    Fastkd3 FAST kinase domains 3 [ Mus musculus (house mouse) ]

    Gene ID: 69577, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fastkd3provided by MGI
    Official Full Name
    FAST kinase domains 3provided by MGI
    Primary source
    MGI:MGI:1916827
    See related
    Ensembl:ENSMUSG00000021532
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW048587; 2310010B21Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.9), CNS E11.5 (RPKM 5.3) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fastkd3 in Genome Data Viewer
    Location:
    13; 13 B3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (68730281..68740457)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (68582167..68592338)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (68721125..68731156)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46386 Neighboring gene VISTA enhancer mm1330 Neighboring gene RIKEN cDNA 1700001L19 gene Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Neighboring gene predicted gene, 34903 Neighboring gene adenylate cyclase 2 Neighboring gene farnesyl diphosphate synthetase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of mitochondrial mRNA stability ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    FAST kinase domain-containing protein 3, mitochondrial

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330423.1NP_001317352.1  FAST kinase domain-containing protein 3, mitochondrial

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK033189, CA560457, CJ265660, CT033781
      Consensus CDS
      CCDS36719.1
      UniProtKB/Swiss-Prot
      Q8BSN9
    2. NM_027123.5NP_081399.3  FAST kinase domain-containing protein 3, mitochondrial

      See identical proteins and their annotated locations for NP_081399.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK033189, CJ265660, CT033781
      Consensus CDS
      CCDS36719.1
      UniProtKB/Swiss-Prot
      Q8BSN9
      Related
      ENSMUSP00000061737.9, ENSMUST00000051784.10
      Conserved Domains (3) summary
      smart00952
      Location:594651
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:410478
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:494580
      FAST_2; FAST kinase-like protein, subdomain 2

    RNA

    1. NR_138477.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK032530, AK033189, CJ265660, CT033781
      Related
      ENSMUST00000223319.2
    2. NR_138478.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' exon and uses alternate splice sites in the second exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AK033189, AW988524, CJ265660, CT033781
      Related
      ENSMUST00000222068.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      68730281..68740457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315595.2XP_017171084.1  FAST kinase domain-containing protein 3, mitochondrial isoform X3

      Conserved Domains (2) summary
      smart00952
      Location:381438
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam08368
      Location:281367
      FAST_2; FAST kinase-like protein, subdomain 2
    2. XM_006517364.4XP_006517427.1  FAST kinase domain-containing protein 3, mitochondrial isoform X1

      Conserved Domains (3) summary
      smart00952
      Location:631688
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:447515
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:531617
      FAST_2; FAST kinase-like protein, subdomain 2
    3. XM_006517366.4XP_006517429.1  FAST kinase domain-containing protein 3, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006517429.1

      Conserved Domains (3) summary
      smart00952
      Location:397454
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:213281
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:297383
      FAST_2; FAST kinase-like protein, subdomain 2
    4. XM_006517367.1XP_006517430.1  FAST kinase domain-containing protein 3, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006517430.1

      Conserved Domains (3) summary
      smart00952
      Location:397454
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:213281
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:297383
      FAST_2; FAST kinase-like protein, subdomain 2

    RNA

    1. XR_004938066.1 RNA Sequence

    2. XR_382449.4 RNA Sequence

    3. XR_003950475.1 RNA Sequence

    4. XR_004938067.1 RNA Sequence

    5. XR_003950476.1 RNA Sequence

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