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    Snx8 sorting nexin 8 [ Mus musculus (house mouse) ]

    Gene ID: 231834, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Snx8provided by MGI
    Official Full Name
    sorting nexin 8provided by MGI
    Primary source
    MGI:MGI:2443816
    See related
    Ensembl:ENSMUSG00000029560 AllianceGenome:MGI:2443816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B130023O14Rik
    Summary
    Predicted to enable identical protein binding activity and phosphatidylinositol binding activity. Predicted to be involved in early endosome to Golgi transport and intracellular protein transport. Predicted to act upstream of or within protein transport. Predicted to be located in early endosome membrane. Predicted to be part of retromer complex. Orthologous to human SNX8 (sorting nexin 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 15.1), spleen adult (RPKM 10.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snx8 in Genome Data Viewer
    Location:
    5 G2; 5 78.95 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140326048..140375063, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140340293..140389308, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene MAD1 mitotic arrest deficient 1-like 1 Neighboring gene predicted gene, 30492 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140619500-140619609 Neighboring gene STARR-seq mESC enhancer starr_14706 Neighboring gene STARR-seq mESC enhancer starr_14707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140684659-140684995 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140686457-140686707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140691391-140691751 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140736675-140736858 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140740159-140740368 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140747294-140747554 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140758495-140758709 Neighboring gene STARR-positive B cell enhancer ABC_E6391 Neighboring gene STARR-seq mESC enhancer starr_14708 Neighboring gene nudix hydrolase 1 Neighboring gene mitochondrial rRNA methyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E9018 Neighboring gene STARR-positive B cell enhancer ABC_E9267 Neighboring gene STARR-positive B cell enhancer ABC_E1696 Neighboring gene predicted gene, 30550 Neighboring gene microRNA 7038 Neighboring gene eukaryotic translation initiation factor 3, subunit B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA. Guo W, et al. Cell Mol Immunol, 2020 Nov. PMID 31511639, Free PMC Article
    2. SNX8 mediates IFNγ-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes. Wei J, et al. Proc Natl Acad Sci U S A, 2017 Dec 5. PMID 29180417, Free PMC Article
    3. Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD. Hu Y, et al. Hepatology, 2021 Nov. PMID 34231239
    4. Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Van Dyck F, et al. Cell Metab, 2007 Nov. PMID 17983586
    5. Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. Sellier C, et al. EMBO J, 2016 Jun 15. PMID 27103069, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD.
      Title: Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD.
    2. SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA.
      Title: SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA.
    3. SNX8 mediates IFNG-triggered non-canonical signaling pathway and host defense against Listeria monocytogenes.
      Title: SNX8 mediates IFNγ-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in early endosome to Golgi transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in early endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172277.3 → NP_758481.1  sorting nexin-8

      See identical proteins and their annotated locations for NP_758481.1

      Status: VALIDATED

      Source sequence(s)
      AC131670, AK148429
      Consensus CDS
      CCDS39356.1
      UniProtKB/Swiss-Prot
      Q8BLI6, Q8BUQ7, Q8CFD4
      UniProtKB/TrEMBL
      Q3U0I9
      Related
      ENSMUSP00000031539.8, ENSMUST00000031539.12
      Conserved Domains (2) summary
      cd06866
      Location:70 → 173
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cd07597
      Location:190 → 434
      BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      140326048..140375063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254436.2 → XP_030110296.1  sorting nexin-8 isoform X3

      UniProtKB/TrEMBL
      Q3U0I9
      Conserved Domains (2) summary
      cd06866
      Location:70 → 173
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cd07597
      Location:176 → 407
      BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8

    2. XM_036165098.1 → XP_036020991.1  sorting nexin-8 isoform X6

      Conserved Domains (1) summary
      cd07597
      Location:1 → 242
      BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8

    3. XM_006504673.4 → XP_006504736.1  sorting nexin-8 isoform X2

      UniProtKB/TrEMBL
      Q3U0I9
      Conserved Domains (2) summary
      cd06866
      Location:71 → 174
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cd07597
      Location:177 → 408
      BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8

    4. XM_006504672.2 → XP_006504735.1  sorting nexin-8 isoform X1

      UniProtKB/TrEMBL
      Q3U0I9
      Related
      ENSMUSP00000142556.2, ENSMUST00000196566.5
      Conserved Domains (2) summary
      cd06866
      Location:71 → 174
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cd07597
      Location:191 → 435
      BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8

    5. XM_030254437.2 → XP_030110297.1  sorting nexin-8 isoform X5

      Conserved Domains (2) summary
      cd06866
      Location:70 → 173
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cl12013
      Location:190 → 300
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_006504674.5 → XP_006504737.1  sorting nexin-8 isoform X4

      Conserved Domains (2) summary
      cd06866
      Location:71 → 174
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cl12013
      Location:191 → 301
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_001784687.3 RNA Sequence

      Related
      ENSMUST00000197880.5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFD4.1 GenPept UniProtKB/Swiss-Prot:Q8CFD4

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