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    Adcy2 adenylate cyclase 2 [ Mus musculus (house mouse) ]

    Gene ID: 210044, updated on 23-Jun-2021

    Summary

    Official Symbol
    Adcy2provided by MGI
    Official Full Name
    adenylate cyclase 2provided by MGI
    Primary source
    MGI:MGI:99676
    See related
    Ensembl:ENSMUSG00000021536
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1060
    Expression
    Biased expression in frontal lobe adult (RPKM 27.4), cortex adult (RPKM 24.4) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Adcy2 in Genome Data Viewer
    Location:
    13 B3; 13 35.55 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (68768162..69147719, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (68620043..68999600, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (68758920..69138419, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700001L19 gene Neighboring gene FAST kinase domains 3 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Neighboring gene predicted gene, 34903 Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene predicted gene, 35161 Neighboring gene predicted gene, 35049 Neighboring gene predicted gene, 26844

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC47193

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G-protein beta/gamma-subunit complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables adenylate cyclase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables adenylate cyclase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    adenylate cyclase type 2
    Names
    ATP pyrophosphate-lyase 2
    adenylate cyclase type II
    adenylyl cyclase 2
    NP_705762.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153534.2NP_705762.2  adenylate cyclase type 2

      See identical proteins and their annotated locations for NP_705762.2

      Status: VALIDATED

      Source sequence(s)
      AI322582, AK132312, BY623048
      Consensus CDS
      CCDS36721.1
      UniProtKB/TrEMBL
      Q3V1Q3
      Related
      ENSMUSP00000022013.8, ENSMUST00000022013.8
      Conserved Domains (4) summary
      smart00044
      Location:240443
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:8821081
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:499603
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:37264
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      68768162..69147719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001780768.2 RNA Sequence

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