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    Kalrn kalirin, RhoGEF kinase [ Mus musculus (house mouse) ]

    Gene ID: 545156, updated on 23-Jun-2021

    Summary

    Official Symbol
    Kalrnprovided by MGI
    Official Full Name
    kalirin, RhoGEF kinaseprovided by MGI
    Primary source
    MGI:MGI:2685385
    See related
    Ensembl:ENSMUSG00000061751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H; DUET; TRAD; Gm539; Hapip; AV235988; 2210407G14Rik; E530005C20Rik
    Expression
    Biased expression in cortex adult (RPKM 11.3), frontal lobe adult (RPKM 7.9) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kalrn in Genome Data Viewer
    Location:
    16; 16 B3
    Exon count:
    69
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33789443..34393647, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33969073..34573277, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (33969159..34514113, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene integrin beta 5 Neighboring gene VISTA enhancer mm268 Neighboring gene uridine monophosphate synthetase Neighboring gene predicted gene, 41448 Neighboring gene ropporin, rhophilin associated protein 1 Neighboring gene predicted gene, 35150 Neighboring gene coiled-coil domain containing 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in NMDA selective glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within behavioral response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within behavioral response to formalin induced pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within habituation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lactation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within maternal behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within maternal process involved in parturition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of growth hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of dendritic spine development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within smooth muscle cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kalirin
    Names
    huntingtin-associated protein interacting protein (duo)
    protein Duo
    serine/threonine kinase with Dbl- and pleckstrin homology domain
    serine/threonine kinase with Dbl- and pleckstrin homology domains
    serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
    NP_001157740.1
    NP_796331.2
    XP_006522426.1
    XP_006522427.1
    XP_006522433.1
    XP_006522443.1
    XP_006522444.1
    XP_006522445.1
    XP_006522446.1
    XP_006522448.1
    XP_006522449.1
    XP_011244253.1
    XP_011244254.1
    XP_011244255.1
    XP_011244256.1
    XP_011244257.1
    XP_011244258.1
    XP_011244259.1
    XP_011244260.1
    XP_011244261.1
    XP_011244262.1
    XP_011244263.1
    XP_011244265.1
    XP_011244267.1
    XP_011244268.1
    XP_011244269.1
    XP_011244270.1
    XP_017172560.1
    XP_017172561.1
    XP_017172562.1
    XP_017172563.1
    XP_017172564.1
    XP_017172565.1
    XP_017172566.1
    XP_017172568.1
    XP_017172569.1
    XP_017172570.1
    XP_017172571.1
    XP_030105050.1
    XP_030105051.1
    XP_030105052.1
    XP_036015907.1
    XP_036015909.1
    XP_036015910.1
    XP_036015912.1
    XP_036015913.1
    XP_036015914.1
    XP_036015916.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164268.1NP_001157740.1  kalirin isoform 2

      See identical proteins and their annotated locations for NP_001157740.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK147518, BC157950
      Consensus CDS
      CCDS49836.1
      UniProtKB/Swiss-Prot
      A2CG49
      Related
      ENSMUSP00000110611.3, ENSMUST00000114960.9
      Conserved Domains (5) summary
      smart00150
      Location:11261226
      SPEC; Spectrin repeats
      smart00516
      Location:39177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12751445
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8911120
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14521574
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    2. NM_177357.3NP_796331.2  kalirin isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
      Source sequence(s)
      AC154524, AC154588, AC165079, CT010573
      Related
      ENSMUSP00000076088.6, ENSMUST00000076810.12
      Conserved Domains (17) summary
      cd00096
      Location:24782552
      Ig; Immunoglobulin domain
      smart00150
      Location:11261226
      SPEC; Spectrin repeats
      cd11852
      Location:16401699
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23142370
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:26742928
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:39177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25592650
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12751445
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8911120
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22422294
      Extensin_2; Extensin-like region
      pfam07679
      Location:24612555
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:14521574
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20962230
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26802927
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:14851570
      PH; PH domain
      pfam00621
      Location:19222092
      RhoGEF; RhoGEF domain
      pfam16609
      Location:16971921
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      33789443..34393647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245955.2XP_011244257.1  kalirin isoform X6

      Conserved Domains (14) summary
      smart00150
      Location:11371237
      SPEC; Spectrin repeats
      cd11852
      Location:16511710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23252381
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:41179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25702661
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12861456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8931131
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22532305
      Extensin_2; Extensin-like region
      cd13240
      Location:14631585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21072241
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26912938
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19332102
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24722566
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17081923
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    2. XM_006522386.4XP_006522449.1  kalirin isoform X45

      Conserved Domains (14) summary
      smart00150
      Location:11211221
      SPEC; Spectrin repeats
      cd11852
      Location:16351694
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23092365
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25342625
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12701440
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8861115
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22372289
      Extensin_2; Extensin-like region
      cd13240
      Location:14471569
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20912225
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26552902
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19172086
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24362530
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:16921907
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    3. XM_006522370.4XP_006522433.1  kalirin isoform X11

      Conserved Domains (14) summary
      smart00150
      Location:11211221
      SPEC; Spectrin repeats
      cd11852
      Location:16351694
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23092365
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25542645
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12701440
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8861115
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22372289
      Extensin_2; Extensin-like region
      cd13240
      Location:14471569
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20912225
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26752922
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19172086
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24562550
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:16921907
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    4. XM_036160016.1XP_036015909.1  kalirin isoform X16

      Conserved Domains (14) summary
      smart00150
      Location:11301230
      SPEC; Spectrin repeats
      cd11852
      Location:16441703
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:22862342
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25312622
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12791449
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:545761
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14561578
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20692203
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26522899
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:18952064
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24332527
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17011892
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24252428
      Ig; Ig strand A [structural motif]
    5. XM_011245956.3XP_011244258.1  kalirin isoform X9

      Conserved Domains (14) summary
      smart00150
      Location:11301230
      SPEC; Spectrin repeats
      cd11852
      Location:16441703
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23182374
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25632654
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12791449
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:545761
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22462298
      Extensin_2; Extensin-like region
      cd13240
      Location:14561578
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21002234
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26842931
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19262095
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24652559
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17011916
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    6. XM_006522364.4XP_006522427.1  kalirin isoform X8

      Conserved Domains (14) summary
      smart00150
      Location:11341234
      SPEC; Spectrin repeats
      cd11852
      Location:16481707
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23222378
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25672658
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12831453
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991128
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22502302
      Extensin_2; Extensin-like region
      cd13240
      Location:14601582
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21042238
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26882935
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19302099
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24692563
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17051920
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    7. XM_011245961.3XP_011244263.1  kalirin isoform X14

      Conserved Domains (14) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:22992355
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25442635
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22272279
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20812215
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26652912
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19072076
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24462540
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17141862
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    8. XM_036160014.1XP_036015907.1  kalirin isoform X4

      Conserved Domains (14) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23292385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25742665
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21122246
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26952942
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19382107
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24762570
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17141895
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:24682471
      Ig; Ig strand A [structural motif]
    9. XM_011245952.3XP_011244254.1  kalirin isoform X2

      Conserved Domains (14) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23302386
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25752666
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22582310
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21122246
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26962943
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19382107
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24772571
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17141928
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    10. XM_017317071.2XP_017172560.1  kalirin isoform X15

      Conserved Domains (14) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:22992355
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25442635
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22282280
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20822216
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26652912
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19082077
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24462540
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17141863
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    11. XM_011245960.3XP_011244262.1  kalirin isoform X13

      Conserved Domains (14) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23002356
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25452636
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22282280
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20822216
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26662913
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19082077
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24472541
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17141863
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    12. XM_011245953.3XP_011244255.1  kalirin isoform X3

      Conserved Domains (14) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23302386
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25752666
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22592311
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21132247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26962943
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19392108
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24772571
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17141929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    13. XM_011245957.3XP_011244259.1  kalirin isoform X10

      Conserved Domains (14) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23312387
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25562647
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22592311
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21132247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26772924
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19392108
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24582552
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17141929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    14. XM_011245951.3XP_011244253.1  kalirin isoform X1

      Conserved Domains (14) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23312387
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25762667
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22592311
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21132247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26972944
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19392108
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24782572
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17141929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    15. XM_006522363.5XP_006522426.1  kalirin isoform X7

      Conserved Domains (14) summary
      smart00150
      Location:11351235
      SPEC; Spectrin repeats
      cd11852
      Location:16491708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23232379
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25682659
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12841454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8911129
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22512303
      Extensin_2; Extensin-like region
      cd13240
      Location:14611583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21052239
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26892936
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19312100
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24702564
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17061921
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    16. XM_011245954.4XP_011244256.1  kalirin isoform X5

      Conserved Domains (14) summary
      smart00150
      Location:11381238
      SPEC; Spectrin repeats
      cd11852
      Location:16521711
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23262382
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:42180
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25712662
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12871457
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8941132
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22542306
      Extensin_2; Extensin-like region
      cd13240
      Location:14641586
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21082242
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26922939
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19342103
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24732567
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17091924
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    17. XM_011245959.3XP_011244261.1  kalirin isoform X12

      See identical proteins and their annotated locations for XP_011244261.1

      Conserved Domains (14) summary
      smart00150
      Location:11171217
      SPEC; Spectrin repeats
      cd11852
      Location:16311690
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23052361
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:21159
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25502641
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12661436
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8731111
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22332285
      Extensin_2; Extensin-like region
      cd13240
      Location:14431565
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20872221
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26712918
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19132082
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24522546
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:16881903
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    18. XM_011245958.3XP_011244260.1  kalirin isoform X12

      See identical proteins and their annotated locations for XP_011244260.1

      Conserved Domains (14) summary
      smart00150
      Location:11171217
      SPEC; Spectrin repeats
      cd11852
      Location:16311690
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23052361
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:21159
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:25502641
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:12661436
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8731111
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22332285
      Extensin_2; Extensin-like region
      cd13240
      Location:14431565
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20872221
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:26712918
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:19132082
      RhoGEF; RhoGEF domain
      pfam07679
      Location:24522546
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:16881903
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    19. XM_006522381.1XP_006522444.1  kalirin isoform X33

      Conserved Domains (13) summary
      smart00150
      Location:481581
      SPEC; Spectrin repeats
      cd11852
      Location:9951054
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:16691725
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd00063
      Location:19142005
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:630800
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:237475
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:15971649
      Extensin_2; Extensin-like region
      cd13240
      Location:807929
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:14511585
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:20352282
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:12771446
      RhoGEF; RhoGEF domain
      pfam07679
      Location:18161910
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:10521267
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    20. XM_036160023.1XP_036015916.1  kalirin isoform X32

      Conserved Domains (13) summary
      smart00150
      Location:485585
      SPEC; Spectrin repeats
      cd11852
      Location:9991058
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:16731729
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd00063
      Location:19182009
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:634804
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:250479
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:811933
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:14551589
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:20392286
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:12811450
      RhoGEF; RhoGEF domain
      pfam07679
      Location:18201914
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:10561238
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:18121815
      Ig; Ig strand A [structural motif]
    21. XM_006522380.1XP_006522443.1  kalirin isoform X31

      Conserved Domains (14) summary
      smart00150
      Location:494594
      SPEC; Spectrin repeats
      cd11852
      Location:10081067
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:16821738
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd00063
      Location:19272018
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:643813
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:250488
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:16101662
      Extensin_2; Extensin-like region
      cd13240
      Location:820942
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:14641598
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:20482295
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      cl02488
      Location:5249
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00621
      Location:12901459
      RhoGEF; RhoGEF domain
      pfam07679
      Location:18291923
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:10651280
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    22. XM_006522385.5XP_006522448.1  kalirin isoform X39

      UniProtKB/TrEMBL
      D3Z4R2
      Related
      ENSMUSP00000110624.2, ENSMUST00000114973.9
      Conserved Domains (7) summary
      cd11853
      Location:627683
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd00063
      Location:872963
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13241
      Location:409543
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:9931240
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:235404
      RhoGEF; RhoGEF domain
      pfam07679
      Location:774868
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:23225
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    23. XM_017317077.3XP_017172566.1  kalirin isoform X40

      Conserved Domains (7) summary
      cd11853
      Location:626682
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd00063
      Location:871962
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13241
      Location:409543
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:9921239
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:235404
      RhoGEF; RhoGEF domain
      pfam07679
      Location:773867
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:23225
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    24. XM_036160017.1XP_036015910.1  kalirin isoform X18

      Conserved Domains (11) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23312387
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21132247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:753999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:19392108
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17141896
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    25. XM_036160019.1XP_036015912.1  kalirin isoform X19

      Conserved Domains (11) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23302386
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21132247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:753999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:19392108
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17141896
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    26. XM_011245963.3XP_011244265.1  kalirin isoform X17

      Conserved Domains (11) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23312387
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22592311
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21132247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:19392108
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17141929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    27. XM_030249191.1XP_030105051.1  kalirin isoform X28

      Conserved Domains (12) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:22992355
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22272279
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20812215
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:753999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:19072076
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17141862
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    28. XM_036160020.1XP_036015913.1  kalirin isoform X23

      Conserved Domains (10) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23302386
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21122246
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:19382107
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17141895
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    29. XM_036160021.1XP_036015914.1  kalirin isoform X27

      Conserved Domains (11) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23002356
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20822216
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:753999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:19082077
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17141905
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    30. XM_011245965.3XP_011244267.1  kalirin isoform X20

      Related
      ENSMUSP00000116188.2, ENSMUST00000142817.8
      Conserved Domains (11) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23312387
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22592311
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21132247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:19392108
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17141929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    31. XM_011245966.3XP_011244268.1  kalirin isoform X21

      Conserved Domains (11) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23312387
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22592311
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21132247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:19392108
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17141929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    32. XM_017317074.2XP_017172563.1  kalirin isoform X30

      Conserved Domains (12) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:22982354
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22272279
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20812215
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:753999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:19072076
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17141862
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    33. XM_030249190.1XP_030105050.1  kalirin isoform X25

      Conserved Domains (11) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23292385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22582310
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21122246
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:19382107
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17141928
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    34. XM_030249192.1XP_030105052.1  kalirin isoform X29

      Conserved Domains (12) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:22992355
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22282280
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20822216
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:753999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:19082077
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17141863
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    35. XM_017317072.3XP_017172561.1  kalirin isoform X22

      Conserved Domains (11) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23302386
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22592311
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21132247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:19392108
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17141929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    36. XM_011245967.3XP_011244269.1  kalirin isoform X24

      Conserved Domains (11) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23302386
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22592311
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21132247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:19392108
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17141929
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    37. XM_017317073.2XP_017172562.1  kalirin isoform X26

      Conserved Domains (12) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16571716
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:23292385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam04554
      Location:22582310
      Extensin_2; Extensin-like region
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21122246
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      TIGR02168
      Location:753999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00621
      Location:19382107
      RhoGEF; RhoGEF domain
      pfam16609
      Location:17141928
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    38. XM_017317082.3XP_017172571.1  kalirin isoform X44

      Conserved Domains (5) summary
      cd11853
      Location:594650
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      pfam04554
      Location:523575
      Extensin_2; Extensin-like region
      cd13241
      Location:377511
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:203372
      RhoGEF; RhoGEF domain
      pfam16609
      Location:23158
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    39. XM_017317080.3XP_017172569.1  kalirin isoform X42

      Conserved Domains (5) summary
      cd11853
      Location:595651
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      pfam04554
      Location:523575
      Extensin_2; Extensin-like region
      cd13241
      Location:377511
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:203372
      RhoGEF; RhoGEF domain
      pfam16609
      Location:23158
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    40. XM_017317081.3XP_017172570.1  kalirin isoform X43

      Conserved Domains (5) summary
      cd11853
      Location:595651
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      pfam04554
      Location:524576
      Extensin_2; Extensin-like region
      cd13241
      Location:378512
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:204373
      RhoGEF; RhoGEF domain
      pfam16609
      Location:23159
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    41. XM_017317079.3XP_017172568.1  kalirin isoform X41

      Related
      ENSMUSP00000110615.2, ENSMUST00000114964.8
      Conserved Domains (5) summary
      cd11853
      Location:596652
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      pfam04554
      Location:524576
      Extensin_2; Extensin-like region
      cd13241
      Location:378512
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:204373
      RhoGEF; RhoGEF domain
      pfam16609
      Location:23159
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    42. XM_017317076.3XP_017172565.1  kalirin isoform X38

      Conserved Domains (5) summary
      smart00150
      Location:11211221
      SPEC; Spectrin repeats
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12701440
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8861115
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14471569
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    43. XM_017317075.3XP_017172564.1  kalirin isoform X37

      Conserved Domains (5) summary
      smart00150
      Location:11301230
      SPEC; Spectrin repeats
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12791449
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:545761
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14561578
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    44. XM_006522383.5XP_006522446.1  kalirin isoform X36

      Conserved Domains (5) summary
      smart00150
      Location:11341234
      SPEC; Spectrin repeats
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12831453
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991128
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14601582
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    45. XM_011245968.4XP_011244270.1  kalirin isoform X34

      Conserved Domains (6) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      smart00516
      Location:47185
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12921462
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8991137
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14691591
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      TIGR02168
      Location:753999
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    46. XM_006522382.5XP_006522445.1  kalirin isoform X35

      UniProtKB/Swiss-Prot
      A2CG49
      Related
      ENSMUSP00000087084.6, ENSMUST00000089655.12
      Conserved Domains (5) summary
      smart00150
      Location:11351235
      SPEC; Spectrin repeats
      smart00516
      Location:39177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12841454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:8911129
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14611583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    RNA

    1. XR_001781845.2 RNA Sequence

    2. XR_001781844.2 RNA Sequence

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