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    Adam2 a disintegrin and metallopeptidase domain 2 [ Mus musculus (house mouse) ]

    Gene ID: 11495, updated on 23-Jun-2021

    Summary

    Official Symbol
    Adam2provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 2provided by MGI
    Primary source
    MGI:MGI:1340894
    See related
    Ensembl:ENSMUSG00000022039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ftn; Ftnb; Ph30-be; AI323749; Ph30-beta
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is predominantly expressed in the epididymis, where the encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Male mice lacking the encoded protein are infertile and exhibit multiple defects in reproduction. [provided by RefSeq, May 2016]
    Expression
    Restricted expression toward testis adult (RPKM 65.0) See more
    Orthologs
    NEW
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    Genomic context

    See Adam2 in Genome Data Viewer
    Location:
    14 D1; 14 34.36 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (66264771..66315300, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (66027322..66077851, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66646166..66696570, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene clusterin Neighboring gene gulonolactone (L-) oxidase Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene epoxide hydrolase 2, cytoplasmic Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 2
    Names
    a disintegrin and metalloprotease domain 2 (fertilin beta)
    fertilin subunit beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009618.3NP_033748.2  disintegrin and metalloproteinase domain-containing protein 2 preproprotein

      See identical proteins and their annotated locations for NP_033748.2

      Status: REVIEWED

      Source sequence(s)
      AC126444, AK016550, BY094547
      Consensus CDS
      CCDS36959.1
      UniProtKB/Swiss-Prot
      Q60718
      Related
      ENSMUSP00000022618.6, ENSMUST00000022618.6
      Conserved Domains (5) summary
      smart00608
      Location:475610
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:185379
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:398469
      Disintegrin; Disintegrin
      pfam01421
      Location:184381
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:40146
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      66264771..66315300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518439.4XP_006518502.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X1

      Conserved Domains (4) summary
      smart00608
      Location:451586
      ACR; ADAM Cysteine-Rich Domain
      pfam00200
      Location:374445
      Disintegrin
      pfam01421
      Location:184357
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:32147
      Pep_M12B_propep; Reprolysin family propeptide
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