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    Adh1 alcohol dehydrogenase 1 (class I) [ Mus musculus (house mouse) ]

    Gene ID: 11522, updated on 26-Sep-2021

    Summary

    Official Symbol
    Adh1provided by MGI
    Official Full Name
    alcohol dehydrogenase 1 (class I)provided by MGI
    Primary source
    MGI:MGI:87921
    See related
    Ensembl:ENSMUSG00000074207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ADH; Adh-; Adh-1; Adh1-; ADH-A2; ADH-AA; Adh-1-; Adh-1e; Adh-1t; Adh-3e; Adh1-e; Adh1-t; Adh1tl; Adh3-e; Adh-1-t; AI194826
    Expression
    Biased expression in liver adult (RPKM 1139.9), adrenal adult (RPKM 886.1) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Adh1 in Genome Data Viewer
    Location:
    3 G3; 3 64.16 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137983346..137996459)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138277585..138290698)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (137940609..137953655)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 0610031O16 gene Neighboring gene alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Neighboring gene predicted gene, 40156 Neighboring gene Adh1 promoter region Neighboring gene predicted gene 16559 Neighboring gene alcohol dehydrogenase 6A (class V)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD-retinol dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NAD-retinol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables alcohol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alcohol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables alcohol dehydrogenase (NAD+) activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables alcohol dehydrogenase activity, zinc-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables alcohol dehydrogenase activity, zinc-dependent ISO
    Inferred from Sequence Orthology
    more info
     
    enables ethanol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables organic cyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in acetaldehyde biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ethanol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ethanol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ethanol oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ethanol oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to steroid hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to testosterone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retinoic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within retinoic acid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within retinoic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within retinoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within retinol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within retinol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alcohol dehydrogenase 1
    Names
    alcohol dehydrogenase 1 temporal, liver
    alcohol dehydrogenase 1, complex
    alcohol dehydrogenase 1, electrophoretic
    alcohol dehydrogenase 3, electrophoretic
    alcohol dehydrogenase A subunit
    class I alcohol dehydrogenase
    NP_031435.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007409.3NP_031435.1  alcohol dehydrogenase 1

      See identical proteins and their annotated locations for NP_031435.1

      Status: VALIDATED

      Source sequence(s)
      AC079682, AI256543, AI326887, CD355981, DV044803
      Consensus CDS
      CCDS17867.1
      UniProtKB/Swiss-Prot
      P00329
      UniProtKB/TrEMBL
      Q3UKA4
      Related
      ENSMUSP00000004232.10, ENSMUST00000004232.10
      Conserved Domains (2) summary
      cd08299
      Location:3375
      alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases
      COG1062
      Location:8375
      FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      137983346..137996459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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