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    Tcf21 transcription factor 21 [ Mus musculus (house mouse) ]

    Gene ID: 21412, updated on 6-Sep-2021

    Summary

    Official Symbol
    Tcf21provided by MGI
    Official Full Name
    transcription factor 21provided by MGI
    Primary source
    MGI:MGI:1202715
    See related
    Ensembl:ENSMUSG00000045680
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Po; ca; ep; Pod; epc; epi; Pod1; Pod-1; bHLHa; bHLHa23; capsulin; epicardin
    Expression
    Biased expression in bladder adult (RPKM 101.3), lung adult (RPKM 85.6) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tcf21 in Genome Data Viewer
    Location:
    10 A3; 10 10.33 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (22693162..22696042, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (22817263..22820143, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (22537069..22539934, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene TATA box binding protein-like 1 Neighboring gene microRNA 7663 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 10824 Neighboring gene predicted gene, 51761 Neighboring gene predicted gene, 46217

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in Sertoli cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in branchiomeric skeletal muscle development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within bronchiole development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in diaphragm development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryonic digestive tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gland development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glomerulus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in metanephric glomerular capillary formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in metanephric mesenchymal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within morphogenesis of a branching structure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of histone deacetylation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within reproductive structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within respiratory system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in roof of mouth development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within sex determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sex differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ureteric bud development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription factor 21
    Names
    podocyte-expressed 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011545.2NP_035675.1  transcription factor 21

      See identical proteins and their annotated locations for NP_035675.1

      Status: VALIDATED

      Source sequence(s)
      AF035717, AK011575
      Consensus CDS
      CCDS23732.1
      UniProtKB/Swiss-Prot
      O35437
      Related
      ENSMUSP00000053178.8, ENSMUST00000049930.9
      Conserved Domains (1) summary
      pfam00010
      Location:80132
      HLH; Helix-loop-helix DNA-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      22693162..22696042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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