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    Snx5 sorting nexin 5 [ Mus musculus (house mouse) ]

    Gene ID: 69178, updated on 23-Jun-2021

    Summary

    Official Symbol
    Snx5provided by MGI
    Official Full Name
    sorting nexin 5provided by MGI
    Primary source
    MGI:MGI:1916428
    See related
    Ensembl:ENSMUSG00000027423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU019504; D2Ertd52; D2Ertd52e; 0910001N05Rik; 1810032P22Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 42.1), liver E14 (RPKM 37.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Snx5 in Genome Data Viewer
    Location:
    2 G1; 2 70.98 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (144092043..144112822, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (144250123..144270902, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (144075862..144096267, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene barrier to autointegration factor 2, opposite strand Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene 5535 Neighboring gene predicted gene, 26165 Neighboring gene small nucleolar RNA, C/D box 17 Neighboring gene mitochondrial genome maintenance exonuclease 1 Neighboring gene ovo like zinc finger 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D1 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dynactin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables dynactin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-5-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermal growth factor catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pinocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in pinocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in macropinocytic cup ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in tubular endosome ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199188.1NP_001186117.1  sorting nexin-5

      See identical proteins and their annotated locations for NP_001186117.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK031873, AL808123, BM120064
      Consensus CDS
      CCDS16815.1
      UniProtKB/Swiss-Prot
      Q9D8U8
      Related
      ENSMUSP00000105657.4, ENSMUST00000110030.10
      Conserved Domains (2) summary
      cd07663
      Location:185402
      BAR_SNX5; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 5
      cl02563
      Location:29169
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    2. NM_024225.5NP_077187.1  sorting nexin-5

      See identical proteins and their annotated locations for NP_077187.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK029463, AK169545, BM120064
      Consensus CDS
      CCDS16815.1
      UniProtKB/Swiss-Prot
      Q9D8U8
      Related
      ENSMUSP00000028909.5, ENSMUST00000028909.5
      Conserved Domains (2) summary
      cd07663
      Location:185402
      BAR_SNX5; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 5
      cl02563
      Location:29169
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      144092043..144112822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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