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    Pgls 6-phosphogluconolactonase [ Mus musculus (house mouse) ]

    Gene ID: 66171, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pglsprovided by MGI
    Official Full Name
    6-phosphogluconolactonaseprovided by MGI
    Primary source
    MGI:MGI:1913421
    See related
    Ensembl:ENSMUSG00000031807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Plgs; AI447866; 1110030K05Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 208.2), ovary adult (RPKM 111.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Pgls in Genome Data Viewer
    Location:
    8 B3.3; 8
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72044828..72048911)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71592184..71596267)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (74116083..74120166)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene nucleoredoxin-like 1 Neighboring gene solute carrier family 27 (fatty acid transporter), member 1 Neighboring gene niban apoptosis regulator 3 Neighboring gene collagen beta(1-O)galactosyltransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 6-phosphogluconolactonase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 6-phosphogluconolactonase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables monosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pentose-phosphate shunt, oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in pentose-phosphate shunt, oxidative branch ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    6-phosphogluconolactonase
    Names
    6PGL
    NP_001281198.1
    NP_079672.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001294269.1NP_001281198.1  6-phosphogluconolactonase isoform 2

      See identical proteins and their annotated locations for NP_001281198.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC162033, AK003134, AK003985, BE654173
      Consensus CDS
      CCDS80895.1
      UniProtKB/Swiss-Prot
      Q9CQ60
      UniProtKB/TrEMBL
      D3Z4X1
      Related
      ENSMUSP00000116524.2, ENSMUST00000143441.2
      Conserved Domains (1) summary
      cd01400
      Location:15156
      6PGL; 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard ...
    2. NM_025396.3NP_079672.1  6-phosphogluconolactonase isoform 1

      See identical proteins and their annotated locations for NP_079672.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC162033
      Consensus CDS
      CCDS22400.1
      UniProtKB/Swiss-Prot
      Q9CQ60
      Related
      ENSMUSP00000034264.5, ENSMUST00000034264.11
      Conserved Domains (1) summary
      TIGR01198
      Location:11247
      pgl; 6-phosphogluconolactonase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      72044828..72048911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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