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    Clca3a1 chloride channel accessory 3A1 [ Mus musculus (house mouse) ]

    Gene ID: 12722, updated on 23-Jun-2021

    Summary

    Official Symbol
    Clca3a1provided by MGI
    Official Full Name
    chloride channel accessory 3A1provided by MGI
    Primary source
    MGI:MGI:1316732
    See related
    Ensembl:ENSMUSG00000056025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clc; Cacc; Clca1
    Expression
    Broad expression in bladder adult (RPKM 11.5), liver E18 (RPKM 11.1) and 18 other tissues See more
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    Genomic context

    See Clca3a1 in Genome Data Viewer
    Location:
    3 H2; 3 69.06 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144435438..144466738, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (144729677..144760977, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (144393280..144423703, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene SH3-domain GRB2-like B1 (endophilin) Neighboring gene BCL2/adenovirus E1B interacting protein 3 pseudogene Neighboring gene predicted gene, 34866 Neighboring gene nuclear receptor subfamily 5, group A, member 2 pseudogene Neighboring gene chloride channel accessory 3A2 Neighboring gene chloride channel accessory 3B Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables intracellular calcium activated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables intracellular calcium activated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloride transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    calcium-activated chloride channel regulator 3A-1
    Names
    chloride channel calcium activated 1
    chloride channel calcium activated 3A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009899.4NP_034029.2  calcium-activated chloride channel regulator 3A-1 precursor

      See identical proteins and their annotated locations for NP_034029.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AC137128, AK137904, AK161805
      Consensus CDS
      CCDS17886.1
      UniProtKB/Swiss-Prot
      Q9QX15
      Related
      ENSMUSP00000054526.6, ENSMUST00000059091.6
      Conserved Domains (1) summary
      TIGR00868
      Location:1865
      hCaCC; calcium-activated chloride channel protein 1

    RNA

    1. NR_130895.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC137128, AK137904, AK161805
      Related
      ENSMUST00000029932.14

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      144435438..144466738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240004.1XP_011238306.1  calcium-activated chloride channel regulator 3A-1 isoform X2

      Conserved Domains (1) summary
      TIGR00868
      Location:35714
      hCaCC; calcium-activated chloride channel protein 1
    2. XM_006500965.5XP_006501028.1  calcium-activated chloride channel regulator 3A-1 isoform X1

      Conserved Domains (1) summary
      TIGR00868
      Location:1788
      hCaCC; calcium-activated chloride channel protein 1

    RNA

    1. XR_004941270.1 RNA Sequence

    2. XR_003954276.2 RNA Sequence

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