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    Map3k8 mitogen-activated protein kinase kinase kinase 8 [ Mus musculus (house mouse) ]

    Gene ID: 26410, updated on 13-Jul-2021

    Summary

    Official Symbol
    Map3k8provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase 8provided by MGI
    Primary source
    MGI:MGI:1346878
    See related
    Ensembl:ENSMUSG00000024235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Co; Tp; Cot; Est; Tpl; Estf; Tpl2; c-CO; Cot/T; Tpl-2; c-COT; Cot/Tpl2
    Expression
    Ubiquitous expression in spleen adult (RPKM 3.1), lung adult (RPKM 2.9) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Map3k8 in Genome Data Viewer
    Location:
    18 A1; 18 2.73 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (4331325..4352978, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (4331325..4352953, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (4331325..4352951, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41657 Neighboring gene carbohydrate sulfotransferase 10 pseudogene Neighboring gene RIKEN cDNA 4833419F23 gene Neighboring gene mitochondrial poly(A) polymerase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (10)  1 citation
    • Chemically induced (ENU) (4) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 8
    Names
    COT proto-oncogene serine/threonine-protein kinase
    cancer Osaka thyroid oncogene
    proto-oncogene c-Cot
    serine/threonine-protein kinase cot
    tumor progression locus 2
    NP_031772.1
    XP_006526007.1
    XP_036017050.1
    XP_036017051.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007746.2NP_031772.1  mitogen-activated protein kinase kinase kinase 8

      See identical proteins and their annotated locations for NP_031772.1

      Status: VALIDATED

      Source sequence(s)
      AC138768
      Consensus CDS
      CCDS29036.1
      UniProtKB/Swiss-Prot
      Q07174
      UniProtKB/TrEMBL
      Q3UEB8
      Related
      ENSMUSP00000025078.3, ENSMUST00000025078.10
      Conserved Domains (2) summary
      smart00220
      Location:146386
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13995
      Location:133388
      STKc_MAP3K8; Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8

    RNA

    1. NR_157375.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK140334, AK171403
      Related
      ENSMUST00000173930.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      4331325..4352978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161157.1XP_036017050.1  mitogen-activated protein kinase kinase kinase 8 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:80211
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006525944.3XP_006526007.1  mitogen-activated protein kinase kinase kinase 8 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:2231
      PKc_like; Protein Kinases, catalytic domain
    3. XM_036161158.1XP_036017051.1  mitogen-activated protein kinase kinase kinase 8 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:65196
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_003952522.2 RNA Sequence

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