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    Ms4a4c membrane-spanning 4-domains, subfamily A, member 4C [ Mus musculus (house mouse) ]

    Gene ID: 64380, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Ms4a4cprovided by MGI
    Official Full Name
    membrane-spanning 4-domains, subfamily A, member 4Cprovided by MGI
    Primary source
    MGI:MGI:1927656
    See related
    Ensembl:ENSMUSG00000024675 AllianceGenome:MGI:1927656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ms4a9; 5830413L19Rik
    Summary
    Predicted to be located in Golgi apparatus; endoplasmic reticulum; and plasma membrane raft. Orthologous to human MS4A4A (membrane spanning 4-domains A4A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 3.3), mammary gland adult (RPKM 2.1) and 7 other tissues See more
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    Genomic context

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    See Ms4a4c in Genome Data Viewer
    Location:
    19 A; 19 8.44 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (11382081..11404610)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (11404717..11427246)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene membrane-spanning 4-domains, subfamily A, member 7 Neighboring gene membrane-spanning 4-domains, subfamily A, member 4A Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene membrane-spanning 4-domains, subfamily A, member 4B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. Ishibashi K, et al. Gene, 2001 Feb 7. PMID 11245982
    2. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Liang Y, et al. Genomics, 2001 Mar 1. PMID 11401424
    3. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article
    4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    membrane-spanning 4-domains, subfamily A, member 4C
    Names
    membrane-spanning 4-domains, subfamily A, member 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029499.3 → NP_083775.1  membrane-spanning 4-domains, subfamily A, member 4C

      See identical proteins and their annotated locations for NP_083775.1

      Status: VALIDATED

      Source sequence(s)
      AC125406, AK151045
      Consensus CDS
      CCDS29599.1
      UniProtKB/TrEMBL
      Q3U5N6, Q99N06, Q9D3F6
      Related
      ENSMUSP00000072512.4, ENSMUST00000072729.10
      Conserved Domains (1) summary
      pfam04103
      Location:43 → 171
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      11382081..11404610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527250.2 → XP_006527313.1  membrane-spanning 4-domains, subfamily A, member 4C isoform X1

      See identical proteins and their annotated locations for XP_006527313.1

      UniProtKB/TrEMBL
      Q3U5N6, Q99N06, Q9D3F6
      Conserved Domains (1) summary
      pfam04103
      Location:43 → 171
      CD20; CD20-like family

    2. XM_006527251.4 → XP_006527314.1  membrane-spanning 4-domains, subfamily A, member 4C isoform X1

      See identical proteins and their annotated locations for XP_006527314.1

      UniProtKB/TrEMBL
      Q3U5N6, Q99N06, Q9D3F6
      Related
      ENSMUSP00000113130.2, ENSMUST00000119366.2
      Conserved Domains (1) summary
      pfam04103
      Location:43 → 171
      CD20; CD20-like family

    3. XM_017318270.2 → XP_017173759.1  membrane-spanning 4-domains, subfamily A, member 4C isoform X2

      Conserved Domains (1) summary
      pfam04103
      Location:10 → 76
      CD20; CD20-like family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_022429.1: Suppressed sequence

      Description
      NM_022429.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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