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    Ccr7 chemokine (C-C motif) receptor 7 [ Mus musculus (house mouse) ]

    Gene ID: 12775, updated on 6-Sep-2021

    Summary

    Official Symbol
    Ccr7provided by MGI
    Official Full Name
    chemokine (C-C motif) receptor 7provided by MGI
    Primary source
    MGI:MGI:103011
    See related
    Ensembl:ENSMUSG00000037944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EBI; EBI1; CCR-7; CD197; Cmkbr; Ebi1h; Cdw197; Cmkbr7; CC-CKR-7
    Expression
    Biased expression in spleen adult (RPKM 74.8), thymus adult (RPKM 70.1) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ccr7 in Genome Data Viewer
    Location:
    11; 11 D
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99035025..99045903, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (99144199..99155077, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (99005513..99016391, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein 4 Neighboring gene tensin 4 Neighboring gene predicted gene, 32249 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables C-C chemokine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables C-C motif chemokine 19 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables C-C motif chemokine 19 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables C-C motif chemokine 21 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables chemokine (C-C motif) ligand 19 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chemokine (C-C motif) ligand 19 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemokine (C-C motif) ligand 21 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chemokine (C-C motif) ligand 21 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of T cell polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in lymph node development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in lymphocyte chemotaxis across high endothelial venule TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in lymphocyte migration into lymph node TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mature conventional dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myeloid dendritic cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of leukocyte apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of positive regulation of JUN kinase activity IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of T cell chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of T cell costimulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T cell proliferation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T-helper 1 cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of cell motility TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of dendritic cell antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of dendritic cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of filopodium assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of humoral immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of hypersensitivity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of immunological synapse formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macrophage chemotaxis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phagocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of receptor-mediated endocytosis IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of thymocyte migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of dendritic cell dendrite assembly IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of tolerance induction to self antigen TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to nitric oxide TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to prostaglandin E TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    C-C chemokine receptor type 7
    Names
    EBV-induced G-protein coupled receptor 1
    MIP-3 beta receptor
    chemokine (C-C) receptor 7
    epstein-Barr virus-induced G-protein coupled receptor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301713.1NP_001288642.1  C-C chemokine receptor type 7 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK037965, BF020112, BY194318
      UniProtKB/Swiss-Prot
      P47774
      Conserved Domains (1) summary
      pfam00001
      Location:12263
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_007719.2NP_031745.2  C-C chemokine receptor type 7 isoform a precursor

      See identical proteins and their annotated locations for NP_031745.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK037965, BF020112
      Consensus CDS
      CCDS25373.1
      UniProtKB/Swiss-Prot
      P47774
      Related
      ENSMUSP00000099423.4, ENSMUST00000103134.4
      Conserved Domains (1) summary
      pfam00001
      Location:75326
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      99035025..99045903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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