Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Postn periostin, osteoblast specific factor [ Mus musculus (house mouse) ]

    Gene ID: 50706, updated on 2-Oct-2021

    Summary

    Official Symbol
    Postnprovided by MGI
    Official Full Name
    periostin, osteoblast specific factorprovided by MGI
    Primary source
    MGI:MGI:1926321
    See related
    Ensembl:ENSMUSG00000027750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Os; PN; Pe; OSF; PLF; Osf2; OSF-2; AI747096; A630052E07Rik
    Summary
    This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in limb E14.5 (RPKM 151.8), placenta adult (RPKM 112.7) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Postn in Genome Data Viewer
    Location:
    3; 3 C
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (54266688..54298462)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (54359267..54391041)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (54165047..54194954)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 4 Neighboring gene predicted gene, 54174 Neighboring gene predicted gene, 31095 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene, 31154

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to vitamin K IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to vitamin K ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    periostin
    Names
    osteoblast specific factor 2 (fasciclin I-like)
    osteoblast-specific factor 2
    periostin-like factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198765.1NP_001185694.1  periostin isoform 2 precursor

      See identical proteins and their annotated locations for NP_001185694.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC139043, AK030756, BE850247, BF020820
      Consensus CDS
      CCDS57211.1
      UniProtKB/Swiss-Prot
      Q62009
      Related
      ENSMUSP00000103619.4, ENSMUST00000107985.10
      Conserved Domains (1) summary
      pfam02469
      Location:247369
      Fasciclin; Fasciclin domain
    2. NM_001198766.1NP_001185695.1  periostin isoform 3 precursor

      See identical proteins and their annotated locations for NP_001185695.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AC139043
      Consensus CDS
      CCDS57212.1
      UniProtKB/Swiss-Prot
      Q62009
      Related
      ENSMUSP00000112735.2, ENSMUST00000117373.8
      Conserved Domains (1) summary
      pfam02469
      Location:247369
      Fasciclin; Fasciclin domain
    3. NM_001313898.1NP_001300827.1  periostin isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate in-frame exon, and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.
      Source sequence(s)
      AC139043
      UniProtKB/TrEMBL
      A0A097BW21
      Conserved Domains (1) summary
      pfam02469
      Location:247369
      Fasciclin; Fasciclin domain
    4. NM_001313899.1NP_001300828.1  periostin isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform 5, which is shorter than isoform 1.
      Source sequence(s)
      AC139043
      UniProtKB/TrEMBL
      A0A097BW18
      Conserved Domains (1) summary
      pfam02469
      Location:247369
      Fasciclin; Fasciclin domain
    5. NM_001368678.1NP_001355607.1  periostin isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains an alternate exon in the 5' UTR and two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform 6, which is longer than isoform 1.
      Source sequence(s)
      AC117594, AC139043
      Consensus CDS
      CCDS89624.1
      Related
      ENSMUSP00000080276.7, ENSMUST00000081564.13
      Conserved Domains (1) summary
      pfam02469
      Location:247369
      Fasciclin; Fasciclin domain
    6. NM_015784.3NP_056599.1  periostin isoform 1 precursor

      See identical proteins and their annotated locations for NP_056599.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC139043, BE850247, BF020820, D13664
      Consensus CDS
      CCDS17351.1
      UniProtKB/Swiss-Prot
      Q62009
      Related
      ENSMUSP00000072773.7, ENSMUST00000073012.13
      Conserved Domains (1) summary
      pfam02469
      Location:247369
      Fasciclin; Fasciclin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      54266688..54298462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center