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    Prc1 protein regulator of cytokinesis 1 [ Mus musculus (house mouse) ]

    Gene ID: 233406, updated on 26-Jul-2021

    Summary

    Official Symbol
    Prc1provided by MGI
    Official Full Name
    protein regulator of cytokinesis 1provided by MGI
    Primary source
    MGI:MGI:1858961
    See related
    Ensembl:ENSMUSG00000038943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D7Ertd348; D7Ertd348e
    Expression
    Broad expression in CNS E11.5 (RPKM 31.2), liver E14 (RPKM 29.8) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Prc1 in Genome Data Viewer
    Location:
    7 D2; 7 45.62 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79944024..79966007)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80294445..80316259)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (87439351..87461145)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene neugrin, neurite outgrowth associated Neighboring gene vacuolar protein sorting 33B Neighboring gene RCC1 domain containing 1 Neighboring gene unc-45 myosin chaperone A Neighboring gene HD domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Chemically induced (ENU) (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6745

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic spindle midzone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in contractile ring ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    protein regulator of cytokinesis 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285997.1NP_001272926.1  protein regulator of cytokinesis 1 isoform 2

      See identical proteins and their annotated locations for NP_001272926.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 4. This variant encodes isoform 2, which is shorter than isoform 4.
      Source sequence(s)
      AC136740, BC059808, CF736005
      Consensus CDS
      CCDS71985.1
      UniProtKB/Swiss-Prot
      Q99K43
      Related
      ENSMUSP00000043379.8, ENSMUST00000047558.14
      Conserved Domains (2) summary
      pfam03999
      Location:37598
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam13094
      Location:34130
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    2. NM_001285998.1NP_001272927.1  protein regulator of cytokinesis 1 isoform 3

      See identical proteins and their annotated locations for NP_001272927.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 4. This variant encodes isoform 3, which is shorter than isoform 4.
      Source sequence(s)
      AC136740, BC059808, CF736005
      Consensus CDS
      CCDS71986.1
      UniProtKB/TrEMBL
      G3UY19
      Related
      ENSMUSP00000133910.2, ENSMUST00000173824.8
      Conserved Domains (1) summary
      pfam03999
      Location:37560
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    3. NM_001374624.1NP_001361553.1  protein regulator of cytokinesis 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AC109232, AC136740
      Consensus CDS
      CCDS90258.1
      Related
      ENSMUSP00000133387.2, ENSMUST00000174172.8
      Conserved Domains (1) summary
      pfam03999
      Location:37615
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    4. NM_001382385.1NP_001369314.1  protein regulator of cytokinesis 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      Conserved Domains (1) summary
      pfam03999
      Location:37549
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    5. NM_001382386.1NP_001369315.1  protein regulator of cytokinesis 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      Conserved Domains (1) summary
      pfam03999
      Location:1496
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    6. NM_001382387.1NP_001369316.1  protein regulator of cytokinesis 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      Conserved Domains (1) summary
      pfam03999
      Location:37517
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    7. NM_001382388.1NP_001369317.1  protein regulator of cytokinesis 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      Conserved Domains (1) summary
      pfam03999
      Location:37612
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    8. NM_001382389.1NP_001369318.1  protein regulator of cytokinesis 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      Conserved Domains (1) summary
      pfam03999
      Location:37614
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    9. NM_001382390.1NP_001369319.1  protein regulator of cytokinesis 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      Conserved Domains (1) summary
      pfam03999
      Location:1440
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    10. NM_145150.3NP_660132.2  protein regulator of cytokinesis 1 isoform 1

      See identical proteins and their annotated locations for NP_660132.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has multiple differences in the coding region but maintains the reading frame, compared to variant 4. This variant encodes isoform 1 which is shorter than isoform 4.
      Source sequence(s)
      AC136740, BC059808, CF736005
      Consensus CDS
      CCDS39998.2
      UniProtKB/TrEMBL
      G3UW86
      Related
      ENSMUSP00000129675.3, ENSMUST00000163812.9
      Conserved Domains (2) summary
      pfam03999
      Location:37601
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam13094
      Location:34130
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79944024..79966007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540855.5XP_006540918.1  protein regulator of cytokinesis 1 isoform X1

      Conserved Domains (1) summary
      pfam03999
      Location:37597
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
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