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    Cr2 complement receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 12902, updated on 6-Jul-2021

    Summary

    Official Symbol
    Cr2provided by MGI
    Official Full Name
    complement receptor 2provided by MGI
    Primary source
    MGI:MGI:88489
    See related
    Ensembl:ENSMUSG00000026616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cr; C3D; Cr-; Cr1; C3DR; CD21; CD35; Cr-1; Cr-2
    Expression
    Biased expression in spleen adult (RPKM 7.1), mammary gland adult (RPKM 1.4) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Cr2 in Genome Data Viewer
    Location:
    1 H6; 1 98.44 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (194819120..194859096, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (195136811..195176880, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (196963005..197002909, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330023F24 gene Neighboring gene microRNA 29c Neighboring gene CD46 antigen, complement regulatory protein Neighboring gene complement component (3b/4b) receptor 1-like Neighboring gene predicted gene, 32313 Neighboring gene predicted gene, 29726 Neighboring gene vomeronasal 2, receptor, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (8)  1 citation
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC130295

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables complement binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables complement receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within bone development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cartilage development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within_negative_effect complement activation, alternative pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in complement activation, alternative pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immunoglobulin mediated immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    complement receptor type 2
    Names
    complement C3d receptor
    complement receptor type 1
    expressed in B lymphocytes

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368765.1NP_001355694.1  complement receptor type 2 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC109145, AC139206
      Consensus CDS
      CCDS87949.1
      Conserved Domains (1) summary
      PHA02927
      Location:10272
      PHA02927; secreted complement-binding protein; Provisional
    2. NM_007758.3NP_031784.1  complement receptor type 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_031784.1

      Status: VALIDATED

      Source sequence(s)
      AC109145, AC139206
      Consensus CDS
      CCDS15642.1
      UniProtKB/TrEMBL
      Q9DC83
      Related
      ENSMUSP00000080938.4, ENSMUST00000082321.9
      Conserved Domains (2) summary
      PHA02639
      Location:17211
      PHA02639; EEV host range protein; Provisional
      PHA02927
      Location:172407
      PHA02927; secreted complement-binding protein; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      194819120..194859096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497225.4XP_006497288.1  complement receptor type 2 isoform X3

      See identical proteins and their annotated locations for XP_006497288.1

      UniProtKB/TrEMBL
      Q9DC83
      Conserved Domains (2) summary
      PHA02639
      Location:17211
      PHA02639; EEV host range protein; Provisional
      PHA02927
      Location:172407
      PHA02927; secreted complement-binding protein; Provisional
    2. XM_006497224.4XP_006497287.1  complement receptor type 2 isoform X2

      Conserved Domains (1) summary
      PHA02927
      Location:293528
      PHA02927; secreted complement-binding protein; Provisional
    3. XM_006497222.4XP_006497285.1  complement receptor type 2 isoform X1

      See identical proteins and their annotated locations for XP_006497285.1

      UniProtKB/TrEMBL
      A0A1B0GS59
      Related
      ENSMUSP00000147804.2, ENSMUST00000210219.2
      Conserved Domains (1) summary
      PHA02927
      Location:10272
      PHA02927; secreted complement-binding protein; Provisional
    4. XM_017314050.3XP_017169539.1  complement receptor type 2 isoform X4

      Conserved Domains (2) summary
      cd00033
      Location:348
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:72307
      PHA02927; secreted complement-binding protein; Provisional

    RNA

    1. XR_865893.3 RNA Sequence

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