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    P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 [ Mus musculus (house mouse) ]

    Gene ID: 18438, updated on 14-Oct-2021

    Summary

    Official Symbol
    P2rx4provided by MGI
    Official Full Name
    purinergic receptor P2X, ligand-gated ion channel 4provided by MGI
    Primary source
    MGI:MGI:1338859
    See related
    Ensembl:ENSMUSG00000029470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P2X4; AI504491; AW555605; D5Ertd444e
    Expression
    Ubiquitous expression in colon adult (RPKM 57.8), lung adult (RPKM 28.0) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See P2rx4 in Genome Data Viewer
    Location:
    5 F; 5 62.53 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122845581..122867802)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122707518..122729739)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (123157566..123179053)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 7 Neighboring gene microRNA 8115 Neighboring gene predicted gene 10064 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 2, beta Neighboring gene anaphase-promoting complex subunit 5 Neighboring gene predicted gene, 33044

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables extracellularly ATP-gated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables extracellularly ATP-gated cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables extracellularly ATP-gated cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables extracellularly ATP-gated cation channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligand-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables purinergic nucleotide receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in behavioral response to pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to ATP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to zinc ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inorganic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microglial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in purinergic nucleotide receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in relaxation of cardiac muscle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ATP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to axon injury ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ischemia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of touch ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    P2X purinoceptor 4
    Names
    ionotropic purinergic receptor
    purinergic receptor P2x4 subunit variant e

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310718.1NP_001297647.1  P2X purinoceptor 4 isoform 2

      See identical proteins and their annotated locations for NP_001297647.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC115728, AK162820, BM244734, BY150918, JX417451
      Consensus CDS
      CCDS80392.1
      UniProtKB/TrEMBL
      D3Z5U5
      Related
      ENSMUSP00000117193.3, ENSMUST00000142664.3
      Conserved Domains (1) summary
      pfam00864
      Location:13339
      P2X_receptor; ATP P2X receptor
    2. NM_001310720.1NP_001297649.1  P2X purinoceptor 4 isoform 3

      See identical proteins and their annotated locations for NP_001297649.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC115728, AF089752, AK162820, BM244734, BY150918
      Consensus CDS
      CCDS80393.1
      UniProtKB/TrEMBL
      Q9Z256
      Related
      ENSMUSP00000080269.7, ENSMUST00000081554.13
      Conserved Domains (1) summary
      pfam00864
      Location:13334
      P2X_receptor; ATP P2X receptor
    3. NM_011026.3NP_035156.2  P2X purinoceptor 4 isoform 1

      See identical proteins and their annotated locations for NP_035156.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC115728, AF089751, AK162820, BM244734, BY150918
      Consensus CDS
      CCDS19654.2
      UniProtKB/TrEMBL
      Q9Z257
      Related
      ENSMUSP00000031429.8, ENSMUST00000031429.14
      Conserved Domains (1) summary
      pfam00864
      Location:13361
      P2X_receptor; ATP P2X receptor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      122845581..122867802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530196.4XP_006530259.1  P2X purinoceptor 4 isoform X1

      UniProtKB/TrEMBL
      D3YYR5
      Related
      ENSMUSP00000118163.3, ENSMUST00000139631.8
      Conserved Domains (1) summary
      cl02993
      Location:1312
      P2X_receptor; ATP P2X receptor
    2. XM_036164869.1XP_036020762.1  P2X purinoceptor 4 isoform X2

      Conserved Domains (1) summary
      pfam00864
      Location:1233
      P2X_receptor; ATP P2X receptor
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