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    Cd8b1 CD8 antigen, beta chain 1 [ Mus musculus (house mouse) ]

    Gene ID: 12526, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cd8b1provided by MGI
    Official Full Name
    CD8 antigen, beta chain 1provided by MGI
    Primary source
    MGI:MGI:88347
    See related
    Ensembl:ENSMUSG00000053044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly-; Cd8b; Ly-3; Ly-C; Lyt-; Lyt-3
    Expression
    Restricted expression toward thymus adult (RPKM 247.7) See more
    Orthologs
    NEW
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    Genomic context

    See Cd8b1 in Genome Data Viewer
    Location:
    6 C1; 6 32.14 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71299772..71314476)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71322788..71337492)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (71272806..71287445)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1070 Neighboring gene predicted gene, 38828 Neighboring gene Cd8 alpha DNase I hypersensitive cluster CIV Neighboring gene Cd8 alpha DNase I hypersensitive cluster CIII Neighboring gene Cd8 alpha DNase I hypersensitive cluster CII Neighboring gene CD8 antigen, alpha chain

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class I protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    T-cell surface glycoprotein CD8 beta chain
    Names
    T-cell membrane glycoprotein Ly-3
    T-cell surface glycoprotein Lyt-3
    lymphocyte antigen 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009858.3NP_033988.1  T-cell surface glycoprotein CD8 beta chain precursor

      See identical proteins and their annotated locations for NP_033988.1

      Status: VALIDATED

      Source sequence(s)
      AK162993, AK169581, BF023006, BY084951
      Consensus CDS
      CCDS39506.1
      UniProtKB/Swiss-Prot
      P10300
      UniProtKB/TrEMBL
      Q3TEK8
      Related
      ENSMUSP00000070131.8, ENSMUST00000065248.9
      Conserved Domains (2) summary
      cd07700
      Location:29135
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
      smart00410
      Location:26135
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      71299772..71314476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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