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    Crem cAMP responsive element modulator [ Mus musculus (house mouse) ]

    Gene ID: 12916, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cremprovided by MGI
    Official Full Name
    cAMP responsive element modulatorprovided by MGI
    Primary source
    MGI:MGI:88495
    See related
    Ensembl:ENSMUSG00000063889 AllianceGenome:MGI:88495
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ICER; ICERI
    Summary
    This gene encodes a basic-leucine zipper domain-containing protein that localizes to gene promoters, where it binds to the cyclic AMP response element (CRE). Different protein isoforms encoded by this gene may function as either activators or repressors of transcription. Activity of this gene is important in multiple developmental processes, including spermatogenesis. Mutation of this gene causes male infertility. Alternative splicing and promoter usage result in multiple transcript variants for this gene. [provided by RefSeq, Oct 2012]
    Expression
    Biased expression in testis adult (RPKM 21.9), liver adult (RPKM 1.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Crem in Genome Data Viewer
    Location:
    18 A1; 18 2.14 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (3263181..3337688, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (3266354..3337773, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, pseudogene 152 Neighboring gene STARR-seq mESC enhancer starr_43652 Neighboring gene STARR-seq mESC enhancer starr_43653 Neighboring gene vomeronasal 1 receptor, 238 Neighboring gene STARR-seq mESC enhancer starr_43654 Neighboring gene STARR-seq mESC enhancer starr_43655 Neighboring gene STARR-positive B cell enhancer ABC_E5646 Neighboring gene predicted gene 6225 Neighboring gene cullin 2 Neighboring gene profilin 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic beta-adrenergic stimulation. Seidl MD, et al. FASEB J, 2020 Aug. PMID 32602979
    2. Novel insights into biological roles of inducible cAMP early repressor ICER. Režen T, et al. Biochem Biophys Res Commun, 2020 Sep 17. PMID 32534736
    3. Transcription Factor CREM Mediates High Glucose Response in Cardiomyocytes and in a Male Mouse Model of Prolonged Hyperglycemia. Barbati SA, et al. Endocrinology, 2017 Jul 1. PMID 28368536
    4. The transcriptional repressor ICER binds to multiple loci throughout the genome. Muñiz LC, et al. Biochem Biophys Res Commun, 2016 Sep 23. PMID 27590584, Free PMC Article
    5. Transcription factor cAMP response element modulator (Crem) restrains Pdgf-dependent proliferation of vascular smooth muscle cells in mice. Seidl MD, et al. Pflugers Arch, 2015 Oct. PMID 25425331, Free PMC Article

    See all (157) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic beta-adrenergic stimulation.
      Title: Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic beta-adrenergic stimulation.
    2. Novel insights into biological roles of inducible cAMP early repressor ICER.
      Title: Novel insights into biological roles of inducible cAMP early repressor ICER.
    3. CREM-/- mice were more susceptible to E. histolytica amebic colitis
      Title: Genome-Wide Association Study Reveals Genetic Link between Diarrhea-Associated Entamoeba histolytica Infection and Inflammatory Bowel Disease.
    4. Studied role and importance of inducible cAMP early repressor (ICER) in glutaminolysis and the generation of Th17 cells. Demonstrated the IL-17 promoting ICER works through the direct control of glutaminase 1 (Gls1) by binding its promoter.
      Title: Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells.
    5. Deficiency in ICER elevated binding of NF-kappaB to promoters of pro-inflammatory genes and their subsequent gene expression. Mice deficient in ICER were hypersensitive to LPS-induced endotoxic shock and showed propagated inflammation.
      Title: A negative feedback loop of ICER and NF-κB regulates TLR signaling in innate immune responses.
    6. The transcription factor CREM was found to be important in the regulation of cardiotoxicity-associated genes.
      Title: Transcription Factor CREM Mediates High Glucose Response in Cardiomyocytes and in a Male Mouse Model of Prolonged Hyperglycemia.
    7. Our results demonstrate that overexpression of CREMalpha in T cells changes the inflammatory milieu, attenuating initiation and progression of CLD.
      Title: Hepatic overexpression of cAMP-responsive element modulator α induces a regulatory T-cell response in a murine model of chronic liver disease.
    8. the role of ICER in ovarian function, was investigated.
      Title: The transcriptional repressor ICER binds to multiple loci throughout the genome.
    9. Phosphorylated Tssk4 might participate in testis genes expressions by phosphorylating Crem at Ser-117.
      Title: Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117.
    10. the signaling pathways mediating GnRH activation of CREB and ICER are distinct, contributing to the decoding of the pulsatile GnRH to regulate FSHbeta expression.
      Title: GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER.
    Submit: New GeneRIF Correction See all GeneRIFs (58)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within glycosphingolipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to cAMP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATF4-CREB1 transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP-responsive element modulator
    Names
    cAMP responsive element moderator
    inducible cAMP early repressor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110850.2 → NP_001104320.1  cAMP-responsive element modulator isoform 4

      See identical proteins and their annotated locations for NP_001104320.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as alpha gamma) lacks three alternate in-frame exons and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC117589, AY738716, BP770366, BQ556287
      UniProtKB/TrEMBL
      F6U9F5
      Related
      ENSMUSP00000115336.2, ENSMUST00000137568.8
      Conserved Domains (2) summary
      cd14690
      Location:177 → 231
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:63 → 102
      pKID; pKID domain

    2. NM_001110851.1 → NP_001104321.1  cAMP-responsive element modulator isoform 7

      See identical proteins and their annotated locations for NP_001104321.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains multiple differences in the UTRs and coding region, including a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (7) contains a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC117589, AK009841, AK010806, AK161366
      Consensus CDS
      CCDS50213.1
      UniProtKB/TrEMBL
      Q3TTH6
      Related
      ENSMUSP00000122282.2, ENSMUST00000142690.2
      Conserved Domains (1) summary
      pfam02173
      Location:96 → 135
      pKID; pKID domain

    3. NM_001110852.1 → NP_001104322.1  cAMP-responsive element modulator isoform 8

      See identical proteins and their annotated locations for NP_001104322.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains multiple differences in the UTRs and coding region, including a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (8) contains a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC117589, AK010806
      Consensus CDS
      CCDS50212.1
      UniProtKB/TrEMBL
      Q9CQ87
      Related
      ENSMUSP00000121210.2, ENSMUST00000149803.8
      Conserved Domains (1) summary
      pfam02173
      Location:47 → 86
      pKID; pKID domain

    4. NM_001110853.2 → NP_001104323.1  cAMP-responsive element modulator isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5'UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (9) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK015641, AK076797, BP770366, BQ556287
      Consensus CDS
      CCDS50211.1
      UniProtKB/TrEMBL
      E9PV35, F6XRJ7
      Related
      ENSMUSP00000121118.2, ENSMUST00000122958.8
      Conserved Domains (2) summary
      cd14690
      Location:248 → 302
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:59 → 98
      pKID; pKID domain

    5. NM_001110854.1 → NP_001104324.2  cAMP-responsive element modulator isoform 10

      See identical proteins and their annotated locations for NP_001104324.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) contains multiple differences in the UTRs and coding region, including lacking multiple exons, compared to variant 1. It represents use of an alternate promoter and contains an alternate 5' coding region. The encoded isoform (10) is shorter and has distinct N- and C- termini, compared to isoform 1.
      Source sequence(s)
      AJ311667, AY738716, BE689077, BP770366, BQ556287
      Consensus CDS
      CCDS50210.2
      UniProtKB/TrEMBL
      F6QWT6, Q78Z98
      Related
      ENSMUSP00000119194.3, ENSMUST00000154705.8
      Conserved Domains (1) summary
      cd14690
      Location:69 → 123
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    6. NM_001110855.1 → NP_001104325.2  cAMP-responsive element modulator isoform 11

      See identical proteins and their annotated locations for NP_001104325.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) contains multiple differences in the UTRs and coding region, including lacking multiple exons, compared to variant 1. It represents use of an alternate promoter and contains an alternate 5' coding region. The encoded isoform (11) is shorter and has distinct N- and C- termini, compared to isoform 1.
      Source sequence(s)
      AJ292222, AY738716, BE689077, BP770366, BQ556287
      Consensus CDS
      CCDS50209.2
      UniProtKB/TrEMBL
      F6VJ22, Q78Z98
      Related
      ENSMUSP00000118578.3, ENSMUST00000151084.8
      Conserved Domains (1) summary
      cd14690
      Location:57 → 111
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    7. NM_001110856.2 → NP_001104326.1  cAMP-responsive element modulator isoform 2

      See identical proteins and their annotated locations for NP_001104326.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as epsilon or tau 1 alpha) lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC117589, AY738718, BP770366, BQ556287
      Consensus CDS
      CCDS50214.1
      UniProtKB/TrEMBL
      F6Q346
      Related
      ENSMUSP00000119353.2, ENSMUST00000131899.8
      Conserved Domains (2) summary
      cd14690
      Location:238 → 292
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    8. NM_001110857.2 → NP_001104327.1  cAMP-responsive element modulator isoform 5

      See identical proteins and their annotated locations for NP_001104327.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as beta) lacks two alternate in-frame exons, compared to variant 1. The structure of this variant is characterized in PMID: 1847666. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC117589
      UniProtKB/TrEMBL
      F6U9F5
      Conserved Domains (2) summary
      cd14690
      Location:189 → 243
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:63 → 102
      pKID; pKID domain

    9. NM_001110858.2 → NP_001104328.1  cAMP-responsive element modulator isoform 6

      See identical proteins and their annotated locations for NP_001104328.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6, also known as gamma) lacks three alternate in-frame exons, compared to variant 1. The structure of this variant is characterized in PMID: 1847666. The encoded isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AC117589
      UniProtKB/TrEMBL
      F6U9F5
      Conserved Domains (2) summary
      cd14690
      Location:177 → 231
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:63 → 102
      pKID; pKID domain

    10. NM_001110859.2 → NP_001104329.1  cAMP-responsive element modulator isoform 1

      See identical proteins and their annotated locations for NP_001104329.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as tau) encodes the longest isoform (1). The structure of this variant is described in PMID: 1370576.
      Source sequence(s)
      AC117589
      Consensus CDS
      CCDS50215.1
      UniProtKB/Swiss-Prot
      P27698, P27699, Q5XTP8, Q5XTP9, Q5XTQ0, Q5XTQ1, Q5XTQ2, Q5XTQ3, Q99JF1
      UniProtKB/TrEMBL
      F6XRJ7
      Conserved Domains (2) summary
      cd14690
      Location:301 → 355
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    11. NM_001271503.1 → NP_001258432.1  cAMP-responsive element modulator isoform 12

      See identical proteins and their annotated locations for NP_001258432.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12, also known as tau 1 gamma) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (12) is shorter than isoform 1.
      Source sequence(s)
      AC117589, AY738715
      UniProtKB/TrEMBL
      F6RB97
      Related
      ENSMUSP00000119638.2, ENSMUST00000146265.8
      Conserved Domains (2) summary
      cd14690
      Location:226 → 280
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    12. NM_001271504.1 → NP_001258433.1  cAMP-responsive element modulator isoform 13

      See identical proteins and their annotated locations for NP_001258433.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13, also known as tau 1 alpha gamma) lacks two alternate in-frame exons and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (13) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC117589, AY738717
      Consensus CDS
      CCDS70863.1
      UniProtKB/TrEMBL
      F6Q346
      Conserved Domains (2) summary
      cd14690
      Location:226 → 280
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    13. NM_001271505.1 → NP_001258434.1  cAMP-responsive element modulator isoform 14

      See identical proteins and their annotated locations for NP_001258434.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14, also known as tau 2 alpha) lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (14) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC117589, AY738719
      Consensus CDS
      CCDS70862.1
      UniProtKB/TrEMBL
      F6W4F5
      Related
      ENSMUSP00000123515.2, ENSMUST00000152900.8
      Conserved Domains (2) summary
      cd14690
      Location:252 → 306
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:63 → 102
      pKID; pKID domain

    14. NM_001271506.1 → NP_001258435.1  cAMP-responsive element modulator isoform 15

      See identical proteins and their annotated locations for NP_001258435.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15, also known as tau alpha gamma) lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (15) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC117589, AY738721
      Consensus CDS
      CCDS70864.1
      UniProtKB/TrEMBL
      F6QKL8
      Related
      ENSMUSP00000121541.2, ENSMUST00000130455.8
      Conserved Domains (2) summary
      cd14690
      Location:289 → 343
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    15. NM_001311066.1 → NP_001297995.1  cAMP-responsive element modulator isoform 16

      See identical proteins and their annotated locations for NP_001297995.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) lacks part of the 5' coding region, uses an alternate 5'-terminal exon and a downstream in-frame start codon, compared to variant 1. The encoded isoform (16) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC117589, AK076797, BP770366, BP771675, CX217456
      Consensus CDS
      CCDS79584.1
      UniProtKB/TrEMBL
      D3Z326, Q78Z98
      Related
      ENSMUSP00000121352.2, ENSMUST00000124747.8
      Conserved Domains (1) summary
      cd14690
      Location:46 → 100
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    16. NM_001311067.1 → NP_001297996.1  cAMP-responsive element modulator isoform 17

      See identical proteins and their annotated locations for NP_001297996.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) lacks part of the 5' coding region, uses an alternate 5'-terminal exon and an alternate start codon, compared to variant 1. The encoded isoform (17) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC117589
      Consensus CDS
      CCDS79585.1
      UniProtKB/TrEMBL
      D3Z6A5, Q78Z98
      Related
      ENSMUSP00000061925.7, ENSMUST00000049942.13
      Conserved Domains (1) summary
      cd14690
      Location:63 → 117
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    17. NM_001374833.1 → NP_001361762.1  cAMP-responsive element modulator isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC117589
      Consensus CDS
      CCDS89179.1
      UniProtKB/TrEMBL
      D3Z2U7, F6QKL8
      Related
      ENSMUSP00000121388.2, ENSMUST00000156234.8
      Conserved Domains (2) summary
      cd14690
      Location:285 → 339
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:96 → 135
      pKID; pKID domain

    18. NM_013498.3 → NP_038526.2  cAMP-responsive element modulator isoform 3

      See identical proteins and their annotated locations for NP_038526.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as alpha) lacks two alternate in-frame exons and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC117589
      Consensus CDS
      CCDS29031.2
      UniProtKB/TrEMBL
      F6U9F5
      Conserved Domains (2) summary
      cd14690
      Location:189 → 243
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:63 → 102
      pKID; pKID domain

    RNA

    1. NR_073193.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) contains multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC117589, AY738720

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      3263181..3337688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525570.3 → XP_006525633.1  cAMP-responsive element modulator isoform X23

      UniProtKB/TrEMBL
      D3Z011, D3Z0R0
      Conserved Domains (2) summary
      cd14690
      Location:224 → 278
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:35 → 74
      pKID; pKID domain

    2. XM_030250301.2 → XP_030106161.1  cAMP-responsive element modulator isoform X9

      UniProtKB/TrEMBL
      D3Z0R0
      Conserved Domains (2) summary
      cd14690
      Location:261 → 315
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:84 → 123
      pKID; pKID domain

    3. XM_030250300.2 → XP_030106160.1  cAMP-responsive element modulator isoform X7

      UniProtKB/TrEMBL
      D3Z0R0
      Conserved Domains (2) summary
      cd14690
      Location:273 → 327
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:84 → 123
      pKID; pKID domain

    4. XM_030250303.2 → XP_030106163.1  cAMP-responsive element modulator isoform X18

      UniProtKB/TrEMBL
      F6XRJ7
      Conserved Domains (2) summary
      cd14690
      Location:236 → 290
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:59 → 98
      pKID; pKID domain

    5. XM_006525579.4 → XP_006525642.1  cAMP-responsive element modulator isoform X39

      See identical proteins and their annotated locations for XP_006525642.1

      UniProtKB/TrEMBL
      D3YVP3
      Related
      ENSMUSP00000114280.2, ENSMUST00000147138.8
      Conserved Domains (1) summary
      cd14690
      Location:69 → 123
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    6. XM_006525580.4 → XP_006525643.1  cAMP-responsive element modulator isoform X40

      See identical proteins and their annotated locations for XP_006525643.1

      UniProtKB/TrEMBL
      D3YVP3
      Related
      ENSMUSP00000115423.2, ENSMUST00000140332.8
      Conserved Domains (1) summary
      cd14690
      Location:57 → 111
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    7. XM_030250313.2 → XP_030106173.1  cAMP-responsive element modulator isoform X41

      UniProtKB/TrEMBL
      D3YVP3
      Conserved Domains (1) summary
      cd14690
      Location:46 → 100
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    8. XM_030250306.2 → XP_030106166.1  cAMP-responsive element modulator isoform X27

      UniProtKB/TrEMBL
      F6RB97
      Conserved Domains (2) summary
      cd14690
      Location:222 → 276
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:96 → 135
      pKID; pKID domain

    9. XM_036160962.1 → XP_036016855.1  cAMP-responsive element modulator isoform X19

      UniProtKB/TrEMBL
      F6W4F5
      Conserved Domains (2) summary
      cd14690
      Location:236 → 290
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:47 → 86
      pKID; pKID domain

    10. XM_036160968.1 → XP_036016861.1  cAMP-responsive element modulator isoform X37

      UniProtKB/TrEMBL
      A0A0R4J1V7, F6U9F5
      Related
      ENSMUSP00000120557.2, ENSMUST00000123672.8
      Conserved Domains (2) summary
      cd14690
      Location:161 → 215
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:47 → 86
      pKID; pKID domain

    11. XM_036160959.1 → XP_036016852.1  cAMP-responsive element modulator isoform X5

      UniProtKB/TrEMBL
      F6XRJ7
      Conserved Domains (2) summary
      cd14690
      Location:285 → 339
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:96 → 135
      pKID; pKID domain

    12. XM_006525565.5 → XP_006525628.1  cAMP-responsive element modulator isoform X15

      See identical proteins and their annotated locations for XP_006525628.1

      UniProtKB/TrEMBL
      F6Q346
      Related
      ENSMUSP00000127353.2, ENSMUST00000165086.8
      Conserved Domains (2) summary
      cd14690
      Location:238 → 292
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    13. XM_036160966.1 → XP_036016859.1  cAMP-responsive element modulator isoform X26

      UniProtKB/TrEMBL
      F6Q346
      Conserved Domains (2) summary
      cd14690
      Location:222 → 276
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:96 → 135
      pKID; pKID domain

    14. XM_030250309.2 → XP_030106169.1  cAMP-responsive element modulator isoform X34

      UniProtKB/TrEMBL
      F6U9F5
      Conserved Domains (2) summary
      cd14690
      Location:173 → 227
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:47 → 86
      pKID; pKID domain

    15. XM_030250308.1 → XP_030106168.1  cAMP-responsive element modulator isoform X28

      UniProtKB/TrEMBL
      F6Q346
      Conserved Domains (2) summary
      cd14690
      Location:210 → 264
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:96 → 135
      pKID; pKID domain

    16. XM_036160967.1 → XP_036016860.1  cAMP-responsive element modulator isoform X29

      UniProtKB/TrEMBL
      F6RB97
      Conserved Domains (2) summary
      cd14690
      Location:210 → 264
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:96 → 135
      pKID; pKID domain

    17. XM_036160960.1 → XP_036016853.1  cAMP-responsive element modulator isoform X8

      UniProtKB/TrEMBL
      F6QKL8
      Conserved Domains (2) summary
      cd14690
      Location:273 → 327
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:96 → 135
      pKID; pKID domain

    18. XM_006525561.5 → XP_006525624.1  cAMP-responsive element modulator isoform X10

      See identical proteins and their annotated locations for XP_006525624.1

      UniProtKB/TrEMBL
      F6W4F5
      Related
      ENSMUSP00000080780.6, ENSMUST00000082141.12
      Conserved Domains (2) summary
      cd14690
      Location:252 → 306
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:63 → 102
      pKID; pKID domain

    19. XM_030250311.1 → XP_030106171.1  cAMP-responsive element modulator isoform X36

      UniProtKB/TrEMBL
      F6U9F5
      Conserved Domains (2) summary
      cd14690
      Location:161 → 215
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:47 → 86
      pKID; pKID domain

    20. XM_030250305.1 → XP_030106165.1  cAMP-responsive element modulator isoform X24

      UniProtKB/TrEMBL
      F6W4F5
      Conserved Domains (2) summary
      cd14690
      Location:224 → 278
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:47 → 86
      pKID; pKID domain

    21. XM_036160965.1 → XP_036016858.1  cAMP-responsive element modulator isoform X25

      UniProtKB/TrEMBL
      F6W4F5
      Conserved Domains (2) summary
      cd14690
      Location:224 → 278
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:47 → 86
      pKID; pKID domain

    22. XM_006525566.5 → XP_006525629.1  cAMP-responsive element modulator isoform X17

      UniProtKB/TrEMBL
      F6W4F5
      Conserved Domains (2) summary
      cd14690
      Location:236 → 290
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:47 → 86
      pKID; pKID domain

    23. XM_036160969.1 → XP_036016862.1  cAMP-responsive element modulator isoform X38

      UniProtKB/TrEMBL
      D3Z773
      Conserved Domains (2) summary
      cd14690
      Location:149 → 203
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:35 → 74
      pKID; pKID domain

    24. XM_030250310.2 → XP_030106170.1  cAMP-responsive element modulator isoform X35

      UniProtKB/TrEMBL
      A0A0R4J1S0, F6U9F5
      Related
      ENSMUSP00000115471.2, ENSMUST00000130599.8
      Conserved Domains (2) summary
      cd14690
      Location:173 → 227
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:47 → 86
      pKID; pKID domain

    25. XM_030250302.1 → XP_030106162.1  cAMP-responsive element modulator isoform X11

      UniProtKB/TrEMBL
      F6W4F5
      Conserved Domains (2) summary
      cd14690
      Location:252 → 306
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:63 → 102
      pKID; pKID domain

    26. XM_036160964.1 → XP_036016857.1  cAMP-responsive element modulator isoform X23

      UniProtKB/TrEMBL
      D3Z011, D3Z0R0
      Related
      ENSMUSP00000120349.2, ENSMUST00000144496.8
      Conserved Domains (2) summary
      cd14690
      Location:224 → 278
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:35 → 74
      pKID; pKID domain

    27. XM_036160963.1 → XP_036016856.1  cAMP-responsive element modulator isoform X22

      UniProtKB/TrEMBL
      D3Z0R0
      Conserved Domains (2) summary
      cd14690
      Location:224 → 278
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:35 → 74
      pKID; pKID domain

    28. XM_006525576.4 → XP_006525639.1  cAMP-responsive element modulator isoform X33

      See identical proteins and their annotated locations for XP_006525639.1

      UniProtKB/TrEMBL
      F6U9F5
      Conserved Domains (2) summary
      cd14690
      Location:177 → 231
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:63 → 102
      pKID; pKID domain

    29. XM_006525575.4 → XP_006525638.1  cAMP-responsive element modulator isoform X32

      See identical proteins and their annotated locations for XP_006525638.1

      UniProtKB/TrEMBL
      F6U9F5
      Conserved Domains (2) summary
      cd14690
      Location:177 → 231
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:63 → 102
      pKID; pKID domain

    30. XM_006525574.4 → XP_006525637.1  cAMP-responsive element modulator isoform X31

      See identical proteins and their annotated locations for XP_006525637.1

      UniProtKB/TrEMBL
      F6U9F5
      Conserved Domains (2) summary
      cd14690
      Location:189 → 243
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:63 → 102
      pKID; pKID domain

    31. XM_006525573.4 → XP_006525636.1  cAMP-responsive element modulator isoform X30

      See identical proteins and their annotated locations for XP_006525636.1

      UniProtKB/TrEMBL
      F6U9F5
      Related
      ENSMUSP00000122051.2, ENSMUST00000154135.8
      Conserved Domains (2) summary
      cd14690
      Location:189 → 243
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:63 → 102
      pKID; pKID domain

    32. XM_006525564.4 → XP_006525627.1  cAMP-responsive element modulator isoform X14

      UniProtKB/TrEMBL
      D3YXV5, F6W4F5
      Related
      ENSMUSP00000118267.2, ENSMUST00000151311.8
      Conserved Domains (2) summary
      cd14690
      Location:240 → 294
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:63 → 102
      pKID; pKID domain

    33. XM_006525563.4 → XP_006525626.1  cAMP-responsive element modulator isoform X13

      UniProtKB/TrEMBL
      F6W4F5
      Conserved Domains (2) summary
      cd14690
      Location:240 → 294
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:63 → 102
      pKID; pKID domain

    34. XM_006525567.4 → XP_006525630.1  cAMP-responsive element modulator isoform X20

      See identical proteins and their annotated locations for XP_006525630.1

      UniProtKB/TrEMBL
      F6Q346
      Related
      ENSMUSP00000118128.2, ENSMUST00000154470.8
      Conserved Domains (2) summary
      cd14690
      Location:226 → 280
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    35. XM_017317808.2 → XP_017173297.1  cAMP-responsive element modulator isoform X16

      UniProtKB/TrEMBL
      F6RB97
      Conserved Domains (2) summary
      cd14690
      Location:238 → 292
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    36. XM_006525557.4 → XP_006525620.1  cAMP-responsive element modulator isoform X4

      UniProtKB/TrEMBL
      F6XRJ7
      Related
      ENSMUSP00000118649.2, ENSMUST00000127601.8
      Conserved Domains (2) summary
      cd14690
      Location:289 → 343
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    37. XM_006525556.4 → XP_006525619.1  cAMP-responsive element modulator isoform X3

      See identical proteins and their annotated locations for XP_006525619.1

      UniProtKB/TrEMBL
      F6QKL8
      Related
      ENSMUSP00000025069.5, ENSMUST00000025069.11
      Conserved Domains (2) summary
      cd14690
      Location:289 → 343
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    38. XM_006525554.4 → XP_006525617.1  cAMP-responsive element modulator isoform X1

      See identical proteins and their annotated locations for XP_006525617.1

      UniProtKB/TrEMBL
      F6QKL8
      Conserved Domains (2) summary
      cd14690
      Location:301 → 355
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    39. XM_011246820.4 → XP_011245122.1  cAMP-responsive element modulator isoform X1

      See identical proteins and their annotated locations for XP_011245122.1

      UniProtKB/TrEMBL
      F6QKL8
      Conserved Domains (2) summary
      cd14690
      Location:301 → 355
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    40. XM_006525559.2 → XP_006525622.1  cAMP-responsive element modulator isoform X6

      See identical proteins and their annotated locations for XP_006525622.1

      UniProtKB/TrEMBL
      D3Z7M6, F6QKL8
      Conserved Domains (2) summary
      cd14690
      Location:273 → 327
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:84 → 123
      pKID; pKID domain

    41. XM_006525560.1 → XP_006525623.1  cAMP-responsive element modulator isoform X6

      See identical proteins and their annotated locations for XP_006525623.1

      UniProtKB/TrEMBL
      D3Z7M6, F6QKL8
      Related
      ENSMUSP00000122179.2, ENSMUST00000154715.8
      Conserved Domains (2) summary
      cd14690
      Location:273 → 327
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:84 → 123
      pKID; pKID domain

    42. XM_006525562.5 → XP_006525625.1  cAMP-responsive element modulator isoform X12

      See identical proteins and their annotated locations for XP_006525625.1

      UniProtKB/TrEMBL
      E9PWV9, F6QKL8
      Related
      ENSMUSP00000114780.2, ENSMUST00000126578.8
      Conserved Domains (2) summary
      cd14690
      Location:248 → 302
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:59 → 98
      pKID; pKID domain

    43. XM_030250315.2 → XP_030106175.1  cAMP-responsive element modulator isoform X42

      UniProtKB/TrEMBL
      D3Z7P7, Q78Z98
      Related
      ENSMUSP00000122123.2, ENSMUST00000139537.2
      Conserved Domains (1) summary
      cd14690
      Location:39 → 93
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    44. XM_006525555.5 → XP_006525618.1  cAMP-responsive element modulator isoform X2

      See identical proteins and their annotated locations for XP_006525618.1

      UniProtKB/Swiss-Prot
      P27698, P27699, Q5XTP8, Q5XTP9, Q5XTQ0, Q5XTQ1, Q5XTQ2, Q5XTQ3, Q99JF1
      UniProtKB/TrEMBL
      F6XRJ7
      Related
      ENSMUSP00000121233.2, ENSMUST00000150235.8
      Conserved Domains (2) summary
      cd14690
      Location:301 → 355
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    45. XM_006525568.5 → XP_006525631.1  cAMP-responsive element modulator isoform X21

      See identical proteins and their annotated locations for XP_006525631.1

      UniProtKB/TrEMBL
      F6RB97
      Conserved Domains (2) summary
      cd14690
      Location:226 → 280
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27699.2 GenPept UniProtKB/Swiss-Prot:P27699

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