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    Ttc7 tetratricopeptide repeat domain 7 [ Mus musculus (house mouse) ]

    Gene ID: 225049, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ttc7provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 7provided by MGI
    Primary source
    MGI:MGI:1920999
    See related
    Ensembl:ENSMUSG00000036918
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    f; he; fsn; hea; Ttc7a; 1110035E02Rik; 1700007L07Rik
    Expression
    Broad expression in duodenum adult (RPKM 23.6), spleen adult (RPKM 20.7) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ttc7 in Genome Data Viewer
    Location:
    17; 17 E4
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (87590245..87689198)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87282808..87381770)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (87682226..87781110)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4833418N02 gene Neighboring gene multiple coagulation factor deficiency 2 Neighboring gene predicted gene, 52284 Neighboring gene uncharacterized LOC102632541 Neighboring gene sperm tail PG rich repeat containing 4 Neighboring gene calmodulin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    flaky skin
    GeneReviews: Not available
    hereditary erythroblastic anemia
    GeneReviews: Not available
    Homozygotes for a spontaneous mutation exhibit reduced growth, sparse hair, thickened, scaly skin, increased numbers of splenic B cells, macrophages, and erythroid cells, elevated IgE, glomerulonephritis, and forestomach papillomas.[MGI]
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 7A
    Names
    TPR repeat protein 7A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028639.3NP_082915.1  tetratricopeptide repeat protein 7A

      See identical proteins and their annotated locations for NP_082915.1

      Status: VALIDATED

      Source sequence(s)
      AK040578, AK080284, AV315613
      Consensus CDS
      CCDS29016.1
      UniProtKB/Swiss-Prot
      Q8BGB2
      Related
      ENSMUSP00000040771.6, ENSMUST00000041110.12
      Conserved Domains (3) summary
      sd00006
      Location:747773
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:712776
      TPR_11; TPR repeat
      pfam13432
      Location:749808
      TPR_16; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      87590245..87689198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160578.1XP_036016471.1  tetratricopeptide repeat protein 7A isoform X2

      Conserved Domains (3) summary
      COG3118
      Location:353443
      YbbN; Negative regulator of GroEL, contains thioredoxin-like and TPR-like domains [Posttranslational modification, protein turnover, chaperones]
      TIGR00990
      Location:492730
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:634660
      TPR; TPR repeat [structural motif]
    2. XM_006524201.5XP_006524264.1  tetratricopeptide repeat protein 7A isoform X1

      Conserved Domains (2) summary
      TIGR00990
      Location:646884
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:788814
      TPR; TPR repeat [structural motif]
    3. XM_006524202.5XP_006524265.1  tetratricopeptide repeat protein 7A isoform X3

      Conserved Domains (3) summary
      COG3118
      Location:507597
      YbbN; Negative regulator of GroEL, contains thioredoxin-like and TPR-like domains [Posttranslational modification, protein turnover, chaperones]
      sd00008
      Location:490525
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:529568
      TPR; TPR repeat [structural motif]
    4. XM_017317451.1XP_017172940.1  tetratricopeptide repeat protein 7A isoform X4

      Conserved Domains (2) summary
      TIGR00990
      Location:350588
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:492518
      TPR; TPR repeat [structural motif]
    5. XM_011246415.3XP_011244717.1  tetratricopeptide repeat protein 7A isoform X5

      Conserved Domains (2) summary
      TIGR00990
      Location:207445
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:349375
      TPR; TPR repeat [structural motif]
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