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    Hrh1 histamine receptor H1 [ Mus musculus (house mouse) ]

    Gene ID: 15465, updated on 6-Sep-2021

    Summary

    Official Symbol
    Hrh1provided by MGI
    Official Full Name
    histamine receptor H1provided by MGI
    Primary source
    MGI:MGI:107619
    See related
    Ensembl:ENSMUSG00000053004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H; Bp; H1R; Hir; Bphs; HH1R
    Expression
    Biased expression in cortex adult (RPKM 2.2), colon adult (RPKM 1.7) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hrh1 in Genome Data Viewer
    Location:
    6 E3; 6 53.05 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (114374897..114460259)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (114397936..114483298)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (114347930..114433290)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter, GABA), member 1 Neighboring gene predicted gene, 38875 Neighboring gene autophagy related 7 Neighboring gene predicted gene, 52917 Neighboring gene calmodulin regulated spectrin-associated protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables histamine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histamine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to histamine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in eosinophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within manganese ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histamine H1 receptor
    Names
    Bordetella pertussis induced histamine sensitization

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252642.2NP_001239571.1  histamine H1 receptor

      See identical proteins and their annotated locations for NP_001239571.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 6. Variants 1 through 6 encode the same protein.
      Source sequence(s)
      AC159381, AK038480, AK046607
      Consensus CDS
      CCDS20435.1
      UniProtKB/Swiss-Prot
      P70174
      UniProtKB/TrEMBL
      B3Y5T0
      Related
      ENSMUSP00000124460.2, ENSMUST00000161650.3
      Conserved Domains (1) summary
      cd15050
      Location:29480
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001252643.2NP_001239572.1  histamine H1 receptor

      See identical proteins and their annotated locations for NP_001239572.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.
      Source sequence(s)
      AC159381, AK038480, AK046607, AK047070
      Consensus CDS
      CCDS20435.1
      UniProtKB/Swiss-Prot
      P70174
      UniProtKB/TrEMBL
      B3Y5T0
      Related
      ENSMUSP00000124037.2, ENSMUST00000161220.2
      Conserved Domains (1) summary
      cd15050
      Location:29480
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001317124.1NP_001304053.1  histamine H1 receptor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.
      Source sequence(s)
      AC159381, AK032763, AK046607
      Consensus CDS
      CCDS20435.1
      UniProtKB/Swiss-Prot
      P70174
      UniProtKB/TrEMBL
      B3Y5T0
      Related
      ENSMUSP00000124320.2, ENSMUST00000160780.2
      Conserved Domains (1) summary
      cd15050
      Location:29480
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_001317125.1NP_001304054.1  histamine H1 receptor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.
      Source sequence(s)
      AC159381, AK046607, BY269581
      Consensus CDS
      CCDS20435.1
      UniProtKB/Swiss-Prot
      P70174
      UniProtKB/TrEMBL
      B3Y5T0
      Conserved Domains (1) summary
      cd15050
      Location:29480
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    5. NM_001317126.1NP_001304055.1  histamine H1 receptor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) represents the longest transcript. Variants 1 thorugh 6 encode the same protein.
      Source sequence(s)
      AC159381, AK046607, BY268114, BY273302
      Consensus CDS
      CCDS20435.1
      UniProtKB/Swiss-Prot
      P70174
      UniProtKB/TrEMBL
      B3Y5T0
      Conserved Domains (1) summary
      cd15050
      Location:29480
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    6. NM_008285.4NP_032311.2  histamine H1 receptor

      See identical proteins and their annotated locations for NP_032311.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 6. Variants 1 through 6 encode the same protein.
      Source sequence(s)
      AC159381, AK046607
      Consensus CDS
      CCDS20435.1
      UniProtKB/Swiss-Prot
      P70174
      UniProtKB/TrEMBL
      B3Y5T0
      Related
      ENSMUSP00000086383.3, ENSMUST00000088987.3
      Conserved Domains (1) summary
      cd15050
      Location:29480
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      114374897..114460259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255192.2XP_030111052.1  histamine H1 receptor isoform X1

      Conserved Domains (1) summary
      cd15050
      Location:29480
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
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