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    Camk4 calcium/calmodulin-dependent protein kinase IV [ Mus musculus (house mouse) ]

    Gene ID: 12326, updated on 27-Jul-2021

    Summary

    Official Symbol
    Camk4provided by MGI
    Official Full Name
    calcium/calmodulin-dependent protein kinase IVprovided by MGI
    Primary source
    MGI:MGI:88258
    See related
    Ensembl:ENSMUSG00000038128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CaM; CaMKI; CaMKIV; AI666733; CaMKIV/Gr; D18Bwg0362e; A430110E23Rik
    Expression
    Biased expression in cerebellum adult (RPKM 21.8), cortex adult (RPKM 9.3) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Camk4 in Genome Data Viewer
    Location:
    18 B1; 18 18.15 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (33067995..33328820)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32934941..33195767)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (33098695..33355421)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930455D15 gene Neighboring gene WD repeat domain 36 Neighboring gene RIKEN cDNA 2310026I22 gene Neighboring gene microRNA 6361 Neighboring gene predicted gene, 54015 Neighboring gene StAR-related lipid transfer (START) domain containing 4 Neighboring gene predicted gene, 41683 Neighboring gene predicted gene, 46640

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myeloid dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron-neuron synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynapse to nucleus signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynapse to nucleus signaling pathway IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in postsynapse to nucleus signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase type IV
    Names
    CAM kinase-GR
    Ca2+/calmodulin-dependent protein kinase type IV/Gr
    caMK IV
    NP_033923.2
    XP_006525606.1
    XP_006525607.1
    XP_006525609.1
    XP_030106157.1
    XP_030106158.1
    XP_036016846.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009793.3NP_033923.2  calcium/calmodulin-dependent protein kinase type IV

      See identical proteins and their annotated locations for NP_033923.2

      Status: VALIDATED

      Source sequence(s)
      AC114919, BC070420, CJ104330
      Consensus CDS
      CCDS29122.1
      UniProtKB/TrEMBL
      Q8BGR3
      Related
      ENSMUSP00000046539.5, ENSMUST00000042868.6
      Conserved Domains (1) summary
      cd14085
      Location:38331
      STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      33067995..33328820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525544.5XP_006525607.1  calcium/calmodulin-dependent protein kinase type IV isoform X2

      See identical proteins and their annotated locations for XP_006525607.1

      UniProtKB/TrEMBL
      Q8BGR3
      Related
      ENSMUSP00000157216.2, ENSMUST00000234654.2
      Conserved Domains (1) summary
      cd14085
      Location:38331
      STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
    2. XM_030250297.2XP_030106157.1  calcium/calmodulin-dependent protein kinase type IV isoform X2

      Conserved Domains (1) summary
      cd14085
      Location:38331
      STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
    3. XM_006525543.3XP_006525606.1  calcium/calmodulin-dependent protein kinase type IV isoform X1

      Conserved Domains (1) summary
      cd14085
      Location:66359
      STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
    4. XM_030250298.2XP_030106158.1  calcium/calmodulin-dependent protein kinase type IV isoform X3

      Conserved Domains (2) summary
      pfam04698
      Location:200251
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
      cl21453
      Location:1138
      PKc_like; Protein Kinases, catalytic domain
    5. XM_006525546.5XP_006525609.1  calcium/calmodulin-dependent protein kinase type IV isoform X2

      See identical proteins and their annotated locations for XP_006525609.1

      UniProtKB/TrEMBL
      Q8BGR3
      Conserved Domains (1) summary
      cd14085
      Location:38331
      STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
    6. XM_036160953.1XP_036016846.1  calcium/calmodulin-dependent protein kinase type IV isoform X3

      Conserved Domains (2) summary
      pfam04698
      Location:200251
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
      cl21453
      Location:1138
      PKc_like; Protein Kinases, catalytic domain
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