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    Gstp1 glutathione S-transferase, pi 1 [ Mus musculus (house mouse) ]

    Gene ID: 14870, updated on 9-Oct-2021

    Summary

    Official Symbol
    Gstp1provided by MGI
    Official Full Name
    glutathione S-transferase, pi 1provided by MGI
    Primary source
    MGI:MGI:95865
    See related
    Ensembl:ENSMUSG00000060803
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gst; GstpiB
    Expression
    Ubiquitous expression in duodenum adult (RPKM 772.3), stomach adult (RPKM 565.6) and 27 other tissues See more
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    Genomic context

    See Gstp1 in Genome Data Viewer
    Location:
    19 A; 19 3.75 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4085411..4087912, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4035411..4037912, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (4035411..4037912, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene double C2, gamma Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1 Neighboring gene glutathione S-transferase, pi 2 Neighboring gene glutathione S-transferase pi 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables JUN kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables S-nitrosoglutathione binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dinitrosyl-iron complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables organic cyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables toxic substance binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in common myeloid progenitor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glutathione derivative biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepoxilin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of acute inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-1 beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of leukocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of monocyte chemotactic protein-1 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of monocyte chemotactic protein-1 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neutrophil aggregation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of nitric-oxide synthase biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of nitric-oxide synthase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of superoxide anion generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to reactive oxygen species IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of TRAF2-GSTP1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    glutathione S-transferase P 1
    Names
    GST YF-YF
    GST class-pi
    GST-piB
    Gst p-1
    gst P1
    preadipocyte growth factor
    NP_038569.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013541.1NP_038569.1  glutathione S-transferase P 1

      See identical proteins and their annotated locations for NP_038569.1

      Status: VALIDATED

      Source sequence(s)
      D30687
      Consensus CDS
      CCDS29411.1
      UniProtKB/Swiss-Prot
      P19157
      Related
      ENSMUSP00000129565.2, ENSMUST00000169613.4
      Conserved Domains (3) summary
      PTZ00057
      Location:6196
      PTZ00057; glutathione s-transferase; Provisional
      cd03210
      Location:84210
      GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases
      cd03076
      Location:376
      GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4085411..4087912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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