Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dlk1 delta like non-canonical Notch ligand 1 [ Mus musculus (house mouse) ]

    Gene ID: 13386, updated on 27-Jul-2021

    Summary

    Official Symbol
    Dlk1provided by MGI
    Official Full Name
    delta like non-canonical Notch ligand 1provided by MGI
    Primary source
    MGI:MGI:94900
    See related
    Ensembl:ENSMUSG00000040856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dl; FA; SC; ZO; pG; FA1; Peg; ZOG; pG2; DlkI; Peg9; SCP1; pref; DLK-1; Ly107; pref-1; AW742678
    Expression
    Biased expression in limb E14.5 (RPKM 294.1), liver E14.5 (RPKM 215.8) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dlk1 in Genome Data Viewer
    Location:
    12 F1; 12 60.17 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (109418411..109429262)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (109452485..109463336)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (110691033..110701546)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52002 Neighboring gene brain-enriched guanylate kinase-associated Neighboring gene macrophage migration inhibitory factor, pseudogene 7 Neighboring gene VISTA enhancer mm799 Neighboring gene predicted gene, 34081 Neighboring gene predicted gene, 34017 Neighboring gene microRNA 1906-1 Neighboring gene maternally expressed 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryo development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of bone remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    protein delta homolog 1
    Names
    adipocyte differentiation inhibitor protein
    delta-like 1 homolog
    fetal antigen 1
    preadipocyte factor 1
    stromal cell derived protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190703.1NP_001177632.1  protein delta homolog 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001177632.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC165954, AK005522, AK162458
      Consensus CDS
      CCDS49173.1
      UniProtKB/TrEMBL
      Q925U3, Q9DAU5
      Related
      ENSMUSP00000105469.2, ENSMUST00000109843.8
      Conserved Domains (1) summary
      cd00054
      Location:88125
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    2. NM_001190704.1NP_001177633.1  protein delta homolog 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001177633.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC165954
      Consensus CDS
      CCDS56863.1
      UniProtKB/TrEMBL
      B4YB46
      Related
      ENSMUSP00000105468.3, ENSMUST00000109842.9
      Conserved Domains (1) summary
      cd00054
      Location:177207
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    3. NM_001190705.1NP_001177634.1  protein delta homolog 1 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001177634.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AC165954
      Consensus CDS
      CCDS49174.1
      UniProtKB/TrEMBL
      B4YB48
      Related
      ENSMUSP00000105472.5, ENSMUST00000109846.11
      Conserved Domains (1) summary
      cd00054
      Location:88125
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    4. NM_010052.5NP_034182.2  protein delta homolog 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034182.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC165954, AK162458
      Consensus CDS
      CCDS26168.1
      UniProtKB/Swiss-Prot
      Q09163
      UniProtKB/TrEMBL
      Q925U3
      Related
      ENSMUSP00000105470.5, ENSMUST00000109844.11
      Conserved Domains (1) summary
      cd00054
      Location:88125
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RNA

    1. NR_033813.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC165954, AK133664, CV562715

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      109418411..109429262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246536.1XP_030102396.1  protein delta homolog 1 isoform X2

      Conserved Domains (1) summary
      cd00054
      Location:177207
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    2. XM_006515457.5XP_006515520.1  protein delta homolog 1 isoform X2

      See identical proteins and their annotated locations for XP_006515520.1

      UniProtKB/TrEMBL
      G3UWU8
      Related
      ENSMUSP00000133430.2, ENSMUST00000173539.8
      Conserved Domains (1) summary
      cd00054
      Location:177207
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    3. XM_011243992.4XP_011242294.1  protein delta homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011242294.1

      Conserved Domains (1) summary
      cd00054
      Location:88125
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    Support Center