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    Ap2b1 adaptor-related protein complex 2, beta 1 subunit [ Mus musculus (house mouse) ]

    Gene ID: 71770, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ap2b1provided by MGI
    Official Full Name
    adaptor-related protein complex 2, beta 1 subunitprovided by MGI
    Primary source
    MGI:MGI:1919020
    See related
    Ensembl:ENSMUSG00000035152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AP105B; AI788979; 1300012O03Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 73.6), CNS E18 (RPKM 36.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ap2b1 in Genome Data Viewer
    Location:
    11; 11 C
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83189545..83295861)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83298719..83405035)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (83116199..83218537)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene schlafen 14 Neighboring gene expressed sequence AA465934 Neighboring gene expressed sequence AI450353 Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene predicted gene, 23951 Neighboring gene RAS-like, family 10, member B Neighboring gene growth arrest-specific 2 like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (2)  1 citation
    • Targeted (1) 
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in clathrin-dependent endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of AP-2 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of clathrin adaptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of clathrin coat ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    AP-2 complex subunit beta
    Names
    adapter-related protein complex 2 beta subunit
    adapter-related protein complex 2 subunit beta
    adaptor protein complex AP-2 subunit beta
    adaptor-related protein complex 2 subunit beta
    beta-2-adaptin
    beta-adaptin
    beta2-adaptin
    clathrin assembly protein complex 2 beta large chain
    plasma membrane adaptor HA2/AP2 adaptin beta subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035854.2NP_001030931.1  AP-2 complex subunit beta isoform a

      See identical proteins and their annotated locations for NP_001030931.1

      Status: VALIDATED

      Source sequence(s)
      AK138434, AL603711
      Consensus CDS
      CCDS25161.1
      UniProtKB/Swiss-Prot
      Q9DBG3
      UniProtKB/TrEMBL
      Q5SWR1
      Related
      ENSMUSP00000018875.7, ENSMUST00000018875.13
      Conserved Domains (4) summary
      smart00809
      Location:731831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    2. NM_027915.3NP_082191.1  AP-2 complex subunit beta isoform b

      See identical proteins and their annotated locations for NP_082191.1

      Status: VALIDATED

      Source sequence(s)
      AK004975, AK138434, AL603711
      Consensus CDS
      CCDS25162.1
      UniProtKB/Swiss-Prot
      Q9DBG3
      UniProtKB/TrEMBL
      Q5SWR1
      Related
      ENSMUSP00000070714.8, ENSMUST00000065692.14
      Conserved Domains (4) summary
      smart00809
      Location:717817
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:826936
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83189545..83295861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314772.3XP_017170261.1  AP-2 complex subunit beta isoform X1

      UniProtKB/Swiss-Prot
      Q9DBG3
      UniProtKB/TrEMBL
      Q5SWR1
      Conserved Domains (4) summary
      smart00809
      Location:731831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    2. XM_006534258.5XP_006534321.1  AP-2 complex subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006534321.1

      UniProtKB/Swiss-Prot
      Q9DBG3
      UniProtKB/TrEMBL
      Q5SWR1
      Related
      ENSMUSP00000135445.2, ENSMUST00000176523.2
      Conserved Domains (4) summary
      smart00809
      Location:731831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    3. XM_036156996.1XP_036012889.1  AP-2 complex subunit beta isoform X1

      Conserved Domains (4) summary
      smart00809
      Location:731831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
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