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    H2-Aa histocompatibility 2, class II antigen A, alpha [ Mus musculus (house mouse) ]

    Gene ID: 14960, updated on 23-Jun-2021

    Summary

    Official Symbol
    H2-Aaprovided by MGI
    Official Full Name
    histocompatibility 2, class II antigen A, alphaprovided by MGI
    Primary source
    MGI:MGI:95895
    See related
    Ensembl:ENSMUSG00000036594
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; I; I-; Ia; H-2; Ia1; H2Aa; Ia-1; H-2Aa; Aalpha; IAalpha; I-Aalpha
    Expression
    Biased expression in spleen adult (RPKM 791.4), large intestine adult (RPKM 638.1) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See H2-Aa in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34501718..34506797, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34282744..34287823, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34419696..34424716, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20506 Neighboring gene histocompatibility 2, class II antigen A, beta 1 Neighboring gene histocompatibility 2, class II antigen E beta Neighboring gene histocompatibility 2, class II antigen E beta2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptide antigen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within antigen processing and presentation of peptide antigen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide antigen assembly with MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MHC class II protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histocompatibility 2, class II antigen A, alpha
    Names
    H-2 class II histocompatibility antigen, A-B alpha chain
    H-2 class II histocompatibility antigen, A-F alpha chain
    H-2 class II histocompatibility antigen, A-K alpha chain
    H-2 class II histocompatibility antigen, A-Q alpha chain
    H-2 class II histocompatibility antigen, A-R alpha chain
    H-2 class II histocompatibility antigen, A-S alpha chain
    H-2 class II histocompatibility antigen, A-U alpha chain
    MHC class II antigen alpha chain
    MHC-II I-A(d) alpha
    histocompatibility 2, class II antigen A, alpha, promoter 1
    major histocompatibility protein class II alpha chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010378.3NP_034508.2  histocompatibility 2, class II antigen A, alpha precursor

      See identical proteins and their annotated locations for NP_034508.2

      Status: VALIDATED

      Source sequence(s)
      AK002532, BY604245, CR974422
      Consensus CDS
      CCDS28645.1
      UniProtKB/Swiss-Prot
      P14434
      Related
      ENSMUSP00000046105.7, ENSMUST00000040655.14
      Conserved Domains (3) summary
      cd05767
      Location:113206
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:31109
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      pfam16196
      Location:204255
      C1-set_C; C1-set C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34501718..34506797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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