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    Myh10 myosin, heavy polypeptide 10, non-muscle [ Mus musculus (house mouse) ]

    Gene ID: 77579, updated on 13-Jun-2021

    Summary

    Official Symbol
    Myh10provided by MGI
    Official Full Name
    myosin, heavy polypeptide 10, non-muscleprovided by MGI
    Primary source
    MGI:MGI:1930780
    See related
    Ensembl:ENSMUSG00000020900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fl; Fltn; Myhn; NM2B; SMem; Myhn-; Myhn2; NMHC-; SMemb; Myhn-2; NMHC-B; NMMHC-B; NMHCII-B; NMHC II-B; NMMHC-IIB; mKIAA3005; NMMHC II-b; 5730504C04Rik; 9330167F11Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 43.2), CNS E14 (RPKM 26.8) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Myh10 in Genome Data Viewer
    Location:
    11 B3; 11 41.95 cM
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68581228..68707451)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68691915..68816626)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (68505417..68630126)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 42 Neighboring gene VISTA enhancer mm213 Neighboring gene uncharacterized LOC118567913 Neighboring gene uncharacterized LOC118567914 Neighboring gene nudE neurodevelopment protein 1 like 1 Neighboring gene ring finger protein 222

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC115764

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within actin filament bundle distribution ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within actin filament-based movement ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actomyosin structure organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adult heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebellar Purkinje cell layer development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fourth ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lateral ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within plasma membrane repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynaptic actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynaptic actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within substrate-dependent cell migration, cell extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within third ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ventricular cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actomyosin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin II complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of myosin II complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myosin II filament ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of polysome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myosin-10
    Names
    cellular myosin heavy chain, type B
    flectin
    myosin IIB
    myosin heavy chain 10, non-muscle
    myosin heavy chain, non-muscle IIb
    myosin heavy chain, nonmuscular, type B
    non-muscle myosin heavy chain B
    non-muscle myosin heavy chain IIb
    nonmuscle myosin heavy chain II-B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175260.2NP_780469.1  myosin-10

      See identical proteins and their annotated locations for NP_780469.1

      Status: VALIDATED

      Source sequence(s)
      AK029236, AK147567, CJ100063
      Consensus CDS
      CCDS24869.1
      UniProtKB/Swiss-Prot
      Q61879
      UniProtKB/TrEMBL
      Q3UH59
      Related
      ENSMUSP00000099671.4, ENSMUST00000102611.10
      Conserved Domains (3) summary
      cd14920
      Location:99771
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8481928
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      68581228..68707451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157089.1XP_036012982.1  myosin-10 isoform X1

      Conserved Domains (3) summary
      cd14920
      Location:99802
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8791959
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain
    2. XM_036157090.1XP_036012983.1  myosin-10 isoform X4

      Conserved Domains (3) summary
      cd14920
      Location:99771
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8481928
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain
    3. XM_006534489.4XP_006534552.1  myosin-10 isoform X1

      UniProtKB/TrEMBL
      Q5SV64
      Related
      ENSMUSP00000018887.9, ENSMUST00000018887.15
      Conserved Domains (3) summary
      cd14920
      Location:99802
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8791959
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain
    4. XM_017314835.3XP_017170324.1  myosin-10 isoform X3

      Conserved Domains (3) summary
      cd14920
      Location:99781
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8581938
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain
    5. XM_017314834.3XP_017170323.1  myosin-10 isoform X2

      Conserved Domains (3) summary
      cd14920
      Location:99792
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8691949
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain
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