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    Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [ Mus musculus (house mouse) ]

    Gene ID: 21355, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tap2provided by MGI
    Official Full Name
    transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)provided by MGI
    Primary source
    MGI:MGI:98484
    See related
    Ensembl:ENSMUSG00000024339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PS; Y1; Ham; MTP; Tap; jas; APT2; Abcb; Ham-; Ham2; MTP2; PSF2; ABC18; Abcb3; Ham-2; Tap-2; RING11; AI462429
    Summary
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with Tap1 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in thymus adult (RPKM 79.3), spleen adult (RPKM 48.3) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Tap2 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34423453..34435295)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34204479..34216321)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34341424..34353266)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Neighboring gene proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Neighboring gene histocompatibility 2, O region beta locus Neighboring gene predicted gene 20506

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (5) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type peptide antigen transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ABC-type peptide antigen transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ABC-type peptide transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to MHC class I protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC class Ib protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables TAP1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables TAP1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables TAP1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TAP2 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to peptide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tapasin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytosol to endoplasmic reticulum transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptide antigen transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptide transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of antigen processing and presentation of peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protection from natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to molecule of bacterial origin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MHC class I peptide loading complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MHC class I peptide loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of TAP complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    antigen peptide transporter 2
    Names
    ATP dependent transport protein family member
    ATP-binding cassette sub-family B member 3
    ATP-binding cassette, sub-family B (MDR/TAP), member 3
    histocompatibility antigen modifier 2
    transporter 2 ATP-binding cassette sub-family B
    transporter 2, ABC (ATP binding cassette)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011530.3NP_035660.3  antigen peptide transporter 2

      See identical proteins and their annotated locations for NP_035660.3

      Status: REVIEWED

      Source sequence(s)
      BE691532, CJ046345, M90459
      Consensus CDS
      CCDS28644.1
      UniProtKB/Swiss-Prot
      P36371
      UniProtKB/TrEMBL
      Q792S7
      Related
      ENSMUSP00000025197.6, ENSMUST00000025197.6
      Conserved Domains (3) summary
      TIGR00958
      Location:1696
      3a01208; Conjugate Transporter-2 (CT2) Family protein
      pfam00664
      Location:155415
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:456679
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34423453..34435295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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