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    Dpysl3 dihydropyrimidinase-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 22240, updated on 5-Sep-2021

    Summary

    Official Symbol
    Dpysl3provided by MGI
    Official Full Name
    dihydropyrimidinase-like 3provided by MGI
    Primary source
    MGI:MGI:1349762
    See related
    Ensembl:ENSMUSG00000024501
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    U; Ul; CRMP; TUC4; Ulip; DRP-3; Ulip1; CRMP-4; ULIP-1
    Summary
    This gene encodes a protein that belongs to the TUC (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are phosphoproteins that function in axonal guidance and neuronal differentiation during development and regeneration of the nervous system. A mutation in the human gene is associated with amyotrophic lateral sclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
    Expression
    Biased expression in CNS E18 (RPKM 272.7), whole brain E14.5 (RPKM 195.1) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dpysl3 in Genome Data Viewer
    Location:
    18; 18 B3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (43454044..43571351, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (43320979..43438286, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (43483881..43552985, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 8181 Neighboring gene serine/threonine kinase 32A Neighboring gene predicted gene, 31647 Neighboring gene predicted gene, 41714 Neighboring gene predicted gene 3650 Neighboring gene eukaryotic translation initiation factor 3, subunit J2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chondroitin sulfate binding ISO
    Inferred from Sequence Orthology
    more info
     
    NOT enables dihydropyrimidinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables filamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with exocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of filamentous actin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dihydropyrimidinase-related protein 3
    Names
    collapsin response mediator protein 4
    unc-33-like phosphoprotein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136086.2NP_001129558.1  dihydropyrimidinase-related protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001129558.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from an alternate start codon compared to variant 3. The encoded isoform (1) has a distinct N-terminus and is shorter than CRMP4b.
      Source sequence(s)
      AC101718, AK133040, BQ175584
      Consensus CDS
      CCDS50269.1
      UniProtKB/TrEMBL
      Q3TT92
      Related
      ENSMUSP00000113711.2, ENSMUST00000118043.8
      Conserved Domains (2) summary
      PRK09060
      Location:15465
      PRK09060; dihydroorotase; Validated
      TIGR02033
      Location:15469
      D-hydantoinase; D-hydantoinase
    2. NM_001291455.1NP_001278384.1  dihydropyrimidinase-related protein 3 CRMP4b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (CRMP4b, also known as isoform 3).
      Source sequence(s)
      AC101718, AK149024, BQ175584
      Consensus CDS
      CCDS79639.1
      UniProtKB/TrEMBL
      E9PWE8
      Related
      ENSMUSP00000112928.2, ENSMUST00000121805.9
      Conserved Domains (2) summary
      PRK09060
      Location:130580
      PRK09060; dihydroorotase; Validated
      TIGR02033
      Location:130584
      D-hydantoinase; D-hydantoinase
    3. NM_009468.5NP_033494.1  dihydropyrimidinase-related protein 3 CRMP4a

      See identical proteins and their annotated locations for NP_033494.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from an alternate start codon compared to variant 3. The encoded isoform (CRMP4a, also known as isoform 2) has a distinct N-terminus and is shorter than CRMP4b.
      Source sequence(s)
      AC101718, BQ175584
      Consensus CDS
      CCDS37801.1
      UniProtKB/Swiss-Prot
      Q62188
      Related
      ENSMUSP00000025379.8, ENSMUST00000025379.14
      Conserved Domains (2) summary
      PRK09060
      Location:17467
      PRK09060; dihydroorotase; Validated
      TIGR02033
      Location:17471
      D-hydantoinase; D-hydantoinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      43454044..43571351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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