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    Heatr6 HEAT repeat containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 217026, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Heatr6provided by MGI
    Official Full Name
    HEAT repeat containing 6provided by MGI
    Primary source
    MGI:MGI:1919790
    See related
    Ensembl:ENSMUSG00000000976 AllianceGenome:MGI:1919790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700008B19Rik
    Summary
    Orthologous to human HEATR6 (HEAT repeat containing 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 7.8), whole brain E14.5 (RPKM 7.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 C; 11 51.23 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83644463..83674580)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83753637..83783754)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene WAP four-disulfide core domain 18 Neighboring gene STARR-positive B cell enhancer ABC_E3982 Neighboring gene STARR-positive B cell enhancer ABC_E9834 Neighboring gene WAP four-disulfide core domain 21 Neighboring gene STARR-positive B cell enhancer ABC_E10701 Neighboring gene STARR-seq mESC enhancer starr_30205 Neighboring gene COMM domain containing 9 pseudogene Neighboring gene predicted gene, 38934

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
    2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22087

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    HEAT repeat-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145432.3 → NP_663407.2  HEAT repeat-containing protein 6

      See identical proteins and their annotated locations for NP_663407.2

      Status: VALIDATED

      Source sequence(s)
      AA183118, AK132494, AK138219, BC065092, DV657360
      Consensus CDS
      CCDS36259.1
      UniProtKB/Swiss-Prot
      Q3UUN8, Q6P1G0, Q99KZ5, Q9CSQ4
      Related
      ENSMUSP00000001002.8, ENSMUST00000001002.8
      Conserved Domains (2) summary
      pfam13251
      Location:421 → 602
      DUF4042; Domain of unknown function (DUF4042)
      sd00044
      Location:817 → 846
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83644463..83674580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314468.2 → XP_017169957.1  HEAT repeat-containing protein 6 isoform X2

      Conserved Domains (2) summary
      sd00044
      Location:353 → 382
      HEAT; HEAT repeat [structural motif]
      pfam13251
      Location:1 → 138
      DUF4042; Domain of unknown function (DUF4042)

    2. XM_030245843.1 → XP_030101703.1  HEAT repeat-containing protein 6 isoform X1

      Conserved Domains (2) summary
      sd00044
      Location:467 → 496
      HEAT; HEAT repeat [structural motif]
      pfam13251
      Location:71 → 252
      DUF4042; Domain of unknown function (DUF4042)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1G0.1 GenPept UniProtKB/Swiss-Prot:Q6P1G0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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