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    Shroom4 shroom family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 208431, updated on 23-Jun-2021

    Summary

    Official Symbol
    Shroom4provided by MGI
    Official Full Name
    shroom family member 4provided by MGI
    Primary source
    MGI:MGI:2685570
    See related
    Ensembl:ENSMUSG00000068270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Shr; Gm724; Shrm4; D430043L16Rik
    Expression
    Broad expression in kidney adult (RPKM 3.7), lung adult (RPKM 2.9) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Shroom4 in Genome Data Viewer
    Location:
    X; X A1.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (6312012..6549508)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (6399949..6637454)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (5977263..6210835)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46685 Neighboring gene bone morphogenetic protein 15 Neighboring gene RIKEN cDNA 5430428K19 gene Neighboring gene diacylglycerol kinase kappa Neighboring gene cyclin B3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables myosin II binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within actin filament organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in apical junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040459.2NP_001035549.1  protein Shroom4 isoform 1

      See identical proteins and their annotated locations for NP_001035549.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL671501, BC151022
      Consensus CDS
      CCDS29959.1
      UniProtKB/Swiss-Prot
      Q1W617
      Related
      ENSMUSP00000100070.4, ENSMUST00000103005.10
      Conserved Domains (3) summary
      cd00992
      Location:1389
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam08687
      Location:12291467
      ASD2; Apx/Shroom domain ASD2
      pfam15265
      Location:229375
      FAM196; FAM196 family
    2. NM_001313764.1NP_001300693.1  protein Shroom4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL671501, BC151022, CJ101431
      UniProtKB/Swiss-Prot
      Q1W617
      Conserved Domains (2) summary
      smart00228
      Location:141
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam08687
      Location:11681416
      ASD2; Apx/Shroom domain ASD2
    3. NM_001313765.1NP_001300694.1  protein Shroom4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate exon in place of the first two exons compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK052531, AK173129, AL671501
      Consensus CDS
      CCDS85744.1
      UniProtKB/Swiss-Prot
      Q1W617
      Related
      ENSMUSP00000086949.3, ENSMUST00000089520.3
      Conserved Domains (1) summary
      pfam08687
      Location:11131351
      ASD2; Apx/Shroom domain ASD2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      6312012..6549508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527549.5XP_006527612.1  protein Shroom4 isoform X1

      Conserved Domains (2) summary
      smart00228
      Location:141
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam08687
      Location:11681416
      ASD2; Apx/Shroom domain ASD2
    2. XM_036161879.1XP_036017772.1  protein Shroom4 isoform X2

      Conserved Domains (1) summary
      smart00228
      Location:141
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

    RNA

    1. XR_001782743.3 RNA Sequence

    2. XR_004940331.1 RNA Sequence

    3. XR_004940332.1 RNA Sequence

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