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    Svil supervillin [ Mus musculus (house mouse) ]

    Gene ID: 225115, updated on 23-Jun-2021

    Summary

    Official Symbol
    Svilprovided by MGI
    Official Full Name
    supervillinprovided by MGI
    Primary source
    MGI:MGI:2147319
    See related
    Ensembl:ENSMUSG00000024236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU024053; B430302E16Rik
    Expression
    Broad expression in bladder adult (RPKM 33.3), heart adult (RPKM 16.5) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Svil in Genome Data Viewer
    Location:
    18; 18 A1
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (4920497..5119293)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (4920467..5119293)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (5046587..5119291)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10556 Neighboring gene predicted gene, 34269 Neighboring gene predicted gene, 41659 Neighboring gene predicted gene, 34326 Neighboring gene uncharacterized LOC115486421 Neighboring gene predicted gene, 26682

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in costamere ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    supervillin
    Names
    archvillin
    p205/p250

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347449.1NP_001334378.1  supervillin isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple in-frame exons in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC115928, AC124770, BP761556
      Consensus CDS
      CCDS84352.1
      UniProtKB/Swiss-Prot
      Q8K4L3
      Conserved Domains (6) summary
      smart00153
      Location:17311766
      VHP; Villin headpiece domain
      cd11280
      Location:11151215
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:14311536
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:9941086
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:12981411
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:15531675
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    2. NM_153153.3NP_694793.1  supervillin isoform a

      See identical proteins and their annotated locations for NP_694793.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC115928, AF317422, AK161114, BC099602
      Consensus CDS
      CCDS37720.1
      UniProtKB/Swiss-Prot
      Q8K4L3
      UniProtKB/TrEMBL
      Q3TTX5
      Related
      ENSMUSP00000025079.10, ENSMUST00000025079.16
      Conserved Domains (6) summary
      smart00153
      Location:21352170
      VHP; Villin headpiece domain
      cd11280
      Location:15191619
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18351940
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13981494
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17021815
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19572079
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      4920497..5119293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161085.1XP_036016978.1  supervillin isoform X12

      Conserved Domains (4) summary
      cd11280
      Location:15361636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14151507
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17191832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:18521925
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    2. XM_006525791.3XP_006525854.1  supervillin isoform X1

      See identical proteins and their annotated locations for XP_006525854.1

      Conserved Domains (6) summary
      smart00153
      Location:21522187
      VHP; Villin headpiece domain
      cd11280
      Location:15361636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18521957
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14151511
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17191832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19742096
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    3. XM_036161072.1XP_036016965.1  supervillin isoform X3

      Conserved Domains (6) summary
      smart00153
      Location:21362171
      VHP; Villin headpiece domain
      cd11280
      Location:15201620
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18361941
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13991495
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17031816
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19582080
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    4. XM_030250413.2XP_030106273.1  supervillin isoform X13

      Conserved Domains (7) summary
      smart00153
      Location:18341869
      VHP; Villin headpiece domain
      cd11280
      Location:12181318
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:15341639
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:10971189
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:14011514
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      PTZ00441
      Location:177335
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      cl15697
      Location:16561778
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    5. XM_030250414.2XP_030106274.1  supervillin isoform X14

      Conserved Domains (6) summary
      smart00153
      Location:17791814
      VHP; Villin headpiece domain
      cd11280
      Location:11631263
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:14791584
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:10421138
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:13461459
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:16011723
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    6. XM_036161087.1XP_036016980.1  supervillin isoform X17

      Related
      ENSMUSP00000119287.2, ENSMUST00000143254.8
      Conserved Domains (6) summary
      smart00153
      Location:17311766
      VHP; Villin headpiece domain
      cd11280
      Location:11151215
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:14311536
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:9941086
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:12981411
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:15531675
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    7. XM_006525789.3XP_006525852.1  supervillin isoform X1

      See identical proteins and their annotated locations for XP_006525852.1

      Conserved Domains (6) summary
      smart00153
      Location:21522187
      VHP; Villin headpiece domain
      cd11280
      Location:15361636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18521957
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14151511
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17191832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19742096
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    8. XM_011246879.3XP_011245181.1  supervillin isoform X5

      Conserved Domains (6) summary
      smart00153
      Location:21202155
      VHP; Villin headpiece domain
      cd11280
      Location:15041604
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18201925
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13831475
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:16871800
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19422064
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    9. XM_011246876.3XP_011245178.1  supervillin isoform X2

      Conserved Domains (6) summary
      smart00153
      Location:21512186
      VHP; Villin headpiece domain
      cd11280
      Location:15351635
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18511956
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14141510
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17181831
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19732095
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    10. XM_006525792.3XP_006525855.1  supervillin isoform X1

      See identical proteins and their annotated locations for XP_006525855.1

      Conserved Domains (6) summary
      smart00153
      Location:21522187
      VHP; Villin headpiece domain
      cd11280
      Location:15361636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18521957
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14151511
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17191832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19742096
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    11. XM_036161071.1XP_036016964.1  supervillin isoform X1

      Conserved Domains (6) summary
      smart00153
      Location:21522187
      VHP; Villin headpiece domain
      cd11280
      Location:15361636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18521957
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14151511
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17191832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19742096
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    12. XM_011246877.4XP_011245179.1  supervillin isoform X3

      Conserved Domains (6) summary
      smart00153
      Location:21362171
      VHP; Villin headpiece domain
      cd11280
      Location:15201620
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18361941
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13991495
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17031816
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19582080
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    13. XM_036161078.1XP_036016971.1  supervillin isoform X6

      Conserved Domains (6) summary
      smart00153
      Location:21042139
      VHP; Villin headpiece domain
      cd11280
      Location:14881588
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18041909
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13671459
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:16711784
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19262048
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    14. XM_011246881.3XP_011245183.1  supervillin isoform X8

      Conserved Domains (6) summary
      smart00153
      Location:20972132
      VHP; Villin headpiece domain
      cd11280
      Location:14811581
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:17971902
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13601456
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:16641777
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19192041
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    15. XM_036161081.1XP_036016974.1  supervillin isoform X10

      Conserved Domains (6) summary
      smart00153
      Location:20812116
      VHP; Villin headpiece domain
      cd11280
      Location:14651565
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:17811886
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13441440
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:16481761
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19032025
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    16. XM_011246878.4XP_011245180.1  supervillin isoform X4

      See identical proteins and their annotated locations for XP_011245180.1

      UniProtKB/Swiss-Prot
      Q8K4L3
      Related
      ENSMUSP00000115078.2, ENSMUST00000126977.8
      Conserved Domains (6) summary
      smart00153
      Location:21352170
      VHP; Villin headpiece domain
      cd11280
      Location:15191619
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18351940
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13981494
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17021815
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19572079
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    17. XM_011246880.3XP_011245182.1  supervillin isoform X7

      Conserved Domains (6) summary
      smart00153
      Location:21032138
      VHP; Villin headpiece domain
      cd11280
      Location:14871587
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18031908
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13661458
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:16701783
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19252047
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    18. XM_036161083.1XP_036016976.1  supervillin isoform X11

      Conserved Domains (6) summary
      smart00153
      Location:20802115
      VHP; Villin headpiece domain
      cd11280
      Location:14641564
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:17801885
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13431439
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:16471760
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19022024
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    19. XM_011246882.4XP_011245184.1  supervillin isoform X13

      Conserved Domains (7) summary
      smart00153
      Location:18341869
      VHP; Villin headpiece domain
      cd11280
      Location:12181318
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:15341639
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:10971189
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:14011514
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      PTZ00441
      Location:177335
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      cl15697
      Location:16561778
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    20. XM_006525800.5XP_006525863.1  supervillin isoform X14

      See identical proteins and their annotated locations for XP_006525863.1

      Conserved Domains (6) summary
      smart00153
      Location:17791814
      VHP; Villin headpiece domain
      cd11280
      Location:11631263
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:14791584
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:10421138
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:13461459
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:16011723
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    21. XM_017317865.3XP_017173354.1  supervillin isoform X15

      Conserved Domains (6) summary
      smart00153
      Location:17631798
      VHP; Villin headpiece domain
      cd11280
      Location:11471247
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:14631568
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:10261122
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:13301443
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:15851707
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    22. XM_011246884.3XP_011245186.1  supervillin isoform X16

      Conserved Domains (6) summary
      smart00153
      Location:17471782
      VHP; Villin headpiece domain
      cd11280
      Location:11311231
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:14471552
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:10101102
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:13141427
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:15691691
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    23. XM_006525801.5XP_006525864.1  supervillin isoform X14

      See identical proteins and their annotated locations for XP_006525864.1

      Conserved Domains (6) summary
      smart00153
      Location:17791814
      VHP; Villin headpiece domain
      cd11280
      Location:11631263
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:14791584
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:10421138
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:13461459
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:16011723
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    24. XM_030250415.2XP_030106275.1  supervillin isoform X17

      Conserved Domains (6) summary
      smart00153
      Location:17311766
      VHP; Villin headpiece domain
      cd11280
      Location:11151215
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:14311536
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:9941086
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:12981411
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:15531675
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    25. XM_036161086.1XP_036016979.1  supervillin isoform X14

      Conserved Domains (6) summary
      smart00153
      Location:17791814
      VHP; Villin headpiece domain
      cd11280
      Location:11631263
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:14791584
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:10421138
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:13461459
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:16011723
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    26. XM_006525790.1XP_006525853.1  supervillin isoform X1

      See identical proteins and their annotated locations for XP_006525853.1

      Conserved Domains (6) summary
      smart00153
      Location:21522187
      VHP; Villin headpiece domain
      cd11280
      Location:15361636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18521957
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14151511
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17191832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19742096
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    27. XM_006525793.5XP_006525856.1  supervillin isoform X1

      See identical proteins and their annotated locations for XP_006525856.1

      Conserved Domains (6) summary
      smart00153
      Location:21522187
      VHP; Villin headpiece domain
      cd11280
      Location:15361636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18521957
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14151511
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17191832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19742096
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    28. XM_036161075.1XP_036016968.1  supervillin isoform X4

      Related
      ENSMUSP00000147843.2, ENSMUST00000210707.2
      Conserved Domains (6) summary
      smart00153
      Location:21352170
      VHP; Villin headpiece domain
      cd11280
      Location:15191619
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18351940
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13981494
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17021815
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19572079
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    29. XM_006525794.5XP_006525857.1  supervillin isoform X1

      See identical proteins and their annotated locations for XP_006525857.1

      Conserved Domains (6) summary
      smart00153
      Location:21522187
      VHP; Villin headpiece domain
      cd11280
      Location:15361636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18521957
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14151511
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17191832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19742096
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    30. XM_036161073.1XP_036016966.1  supervillin isoform X3

      Conserved Domains (6) summary
      smart00153
      Location:21362171
      VHP; Villin headpiece domain
      cd11280
      Location:15201620
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18361941
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13991495
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17031816
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19582080
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    31. XM_036161076.1XP_036016969.1  supervillin isoform X4

      Related
      ENSMUSP00000119803.2, ENSMUST00000140448.8
      Conserved Domains (6) summary
      smart00153
      Location:21352170
      VHP; Villin headpiece domain
      cd11280
      Location:15191619
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18351940
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13981494
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17021815
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19572079
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    32. XM_036161074.1XP_036016967.1  supervillin isoform X3

      Conserved Domains (6) summary
      smart00153
      Location:21362171
      VHP; Villin headpiece domain
      cd11280
      Location:15201620
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18361941
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13991495
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17031816
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19582080
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    33. XM_036161077.1XP_036016970.1  supervillin isoform X4

      Conserved Domains (6) summary
      smart00153
      Location:21352170
      VHP; Villin headpiece domain
      cd11280
      Location:15191619
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18351940
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13981494
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17021815
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19572079
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    34. XM_036161080.1XP_036016973.1  supervillin isoform X9

      Conserved Domains (6) summary
      smart00153
      Location:20962131
      VHP; Villin headpiece domain
      cd11280
      Location:14801580
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:17961901
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13591455
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:16631776
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19182040
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    35. XM_036161079.1XP_036016972.1  supervillin isoform X6

      Conserved Domains (6) summary
      smart00153
      Location:21042139
      VHP; Villin headpiece domain
      cd11280
      Location:14881588
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18041909
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13671459
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:16711784
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19262048
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    36. XM_036161082.1XP_036016975.1  supervillin isoform X10

      Conserved Domains (6) summary
      smart00153
      Location:20812116
      VHP; Villin headpiece domain
      cd11280
      Location:14651565
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:17811886
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13441440
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:16481761
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19032025
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    37. XM_036161084.1XP_036016977.1  supervillin isoform X11

      Conserved Domains (6) summary
      smart00153
      Location:20802115
      VHP; Villin headpiece domain
      cd11280
      Location:14641564
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:17801885
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13431439
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:16471760
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19022024
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178046.3: Suppressed sequence

      Description
      NM_178046.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center