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    Cxcl1 chemokine (C-X-C motif) ligand 1 [ Mus musculus (house mouse) ]

    Gene ID: 14825, updated on 12-Sep-2021

    Summary

    Official Symbol
    Cxcl1provided by MGI
    Official Full Name
    chemokine (C-X-C motif) ligand 1provided by MGI
    Primary source
    MGI:MGI:108068
    See related
    Ensembl:ENSMUSG00000029380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F; Gr; KC; Mg; N5; Fsp; N51; gro; Gro1; Mgsa; Scyb; Scyb1
    Summary
    This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]
    Expression
    Broad expression in ovary adult (RPKM 2.9), placenta adult (RPKM 2.3) and 22 other tissues See more
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    Genomic context

    See Cxcl1 in Genome Data Viewer
    Location:
    5 E1; 5 44.78 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (91039104..91040980)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90891245..90893121)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (91320271..91322147)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) ligand 3 Neighboring gene chemokine (C-X-C motif) ligand 15 Neighboring gene chemokine (C-X-C motif) ligand 2 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like Neighboring gene predicted gene, 52819

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CXCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chemokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in acute inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neutrophil mediated killing of fungus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of superoxide anion generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    growth-regulated alpha protein
    Names
    C-X-C motif chemokine 1
    GRO1 oncogene
    KC/GR)-alpha
    KC/GRO-alpha
    alpha-chemokine
    platelet-derived growth factor-inducible protein KC
    secretory protein N51

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008176.3NP_032202.1  growth-regulated alpha protein precursor

      See identical proteins and their annotated locations for NP_032202.1

      Status: REVIEWED

      Source sequence(s)
      BQ031102, BY335927
      Consensus CDS
      CCDS39143.1
      UniProtKB/Swiss-Prot
      P12850
      UniProtKB/TrEMBL
      A2RTH0
      Related
      ENSMUSP00000031327.9, ENSMUST00000031327.9
      Conserved Domains (1) summary
      cd00273
      Location:3092
      Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      91039104..91040980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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