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    Cx3cl1 chemokine (C-X3-C motif) ligand 1 [ Mus musculus (house mouse) ]

    Gene ID: 20312, updated on 26-Jun-2021

    Summary

    Official Symbol
    Cx3cl1provided by MGI
    Official Full Name
    chemokine (C-X3-C motif) ligand 1provided by MGI
    Primary source
    MGI:MGI:1097153
    See related
    Ensembl:ENSMUSG00000031778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FK; CX3C; Cxc3; Scyd; Scyd1; fract; neuro; ABCD-3; AB030188; AI848747; D8Bwg0439e
    Expression
    Biased expression in cortex adult (RPKM 170.7), frontal lobe adult (RPKM 132.2) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cx3cl1 in Genome Data Viewer
    Location:
    8 C5; 8 46.79 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95498808..95509055)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94772180..94782427)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (97296080..97306327)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-C motif) ligand 22 Neighboring gene guanine nucleotide binding protein (G protein), beta 1, pseudogene 3 Neighboring gene predicted gene, 51543 Neighboring gene RIKEN cDNA 1700121C10 gene Neighboring gene chemokine (C-C motif) ligand 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables CX3C chemokine receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables CX3C chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables CXCR1 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chemokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chemokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within angiogenesis involved in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autocrine signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interferon-gamma IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to interleukin-1 IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chemokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eosinophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in inhibitory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte adhesive activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukocyte migration involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lymphocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within lymphocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within macrophage chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microglial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hippocampal neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-1 alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of I-kappaB phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of calcium-independent cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microglial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transforming growth factor beta1 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ischemia ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fractalkine
    Names
    C-X3-C motif chemokine 1
    CX3C membrane-anchored chemokine
    neurotactin
    small inducible cytokine subfamily D, 1
    small-inducible cytokine D1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009142.3NP_033168.2  fractalkine precursor

      See identical proteins and their annotated locations for NP_033168.2

      Status: VALIDATED

      Source sequence(s)
      AC123826, AK138214, CB526167
      Consensus CDS
      CCDS22548.1
      UniProtKB/Swiss-Prot
      O35188
      Related
      ENSMUSP00000034230.6, ENSMUST00000034230.7
      Conserved Domains (1) summary
      cd00274
      Location:25100
      Chemokine_CX3C; Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      95498808..95509055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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