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    Pafah1b3 platelet-activating factor acetylhydrolase, isoform 1b, subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 18476, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pafah1b3provided by MGI
    Official Full Name
    platelet-activating factor acetylhydrolase, isoform 1b, subunit 3provided by MGI
    Primary source
    MGI:MGI:108414
    See related
    Ensembl:ENSMUSG00000005447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Paf; mus[g; Pafahg; mus[g]
    Expression
    Broad expression in whole brain E14.5 (RPKM 110.4), CNS E14 (RPKM 96.3) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pafah1b3 in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24994473..24997411, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25295048..25297986, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (26080068..26082974, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118567476 Neighboring gene predicted gene, 45974 Neighboring gene capicua transcriptional repressor Neighboring gene proline rich 19 Neighboring gene transmembrane protein 145

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables platelet-activating factor acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to platelet-activating factor acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    platelet-activating factor acetylhydrolase IB subunit alpha1; platelet-activating factor acetylhydrolase IB subunit gamma
    Names
    PAF acetylhydrolase 29 kDa subunit
    PAF-AH 29 kDa subunit
    PAF-AH gamma
    PAF-AH subunit gamma
    PAFAH subunit gamma
    NP_001344279.1
    NP_032802.1
    XP_017177516.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357350.1NP_001344279.1  platelet-activating factor acetylhydrolase IB subunit alpha1

      Status: VALIDATED

      Source sequence(s)
      AC156992
      Consensus CDS
      CCDS20979.1
      Conserved Domains (1) summary
      cd01820
      Location:8206
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
    2. NM_008776.2NP_032802.1  platelet-activating factor acetylhydrolase IB subunit alpha1

      See identical proteins and their annotated locations for NP_032802.1

      Status: VALIDATED

      Source sequence(s)
      AC156992, BC067015
      Consensus CDS
      CCDS20979.1
      UniProtKB/Swiss-Prot
      Q61205
      UniProtKB/TrEMBL
      Q3TJC2
      Related
      ENSMUSP00000005583.6, ENSMUST00000005583.12
      Conserved Domains (1) summary
      cd01820
      Location:8206
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24994473..24997411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322027.2XP_017177516.1  platelet-activating factor acetylhydrolase IB subunit gamma isoform X1

      UniProtKB/Swiss-Prot
      Q61205
      UniProtKB/TrEMBL
      Q3TJC2
      Conserved Domains (1) summary
      cd01820
      Location:8206
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
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