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    Aldoa aldolase A, fructose-bisphosphate [ Mus musculus (house mouse) ]

    Gene ID: 11674, updated on 23-Jun-2021

    Summary

    Official Symbol
    Aldoaprovided by MGI
    Official Full Name
    aldolase A, fructose-bisphosphateprovided by MGI
    Primary source
    MGI:MGI:87994
    See related
    Ensembl:ENSMUSG00000030695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Al; Ald; Aldo1; Aldo-1
    Expression
    Broad expression in mammary gland adult (RPKM 794.0), subcutaneous fat pad adult (RPKM 494.9) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Aldoa in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126394406..126400166, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126795234..126800994, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (133938748..133943961, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene T-box 6 Neighboring gene protein phosphatase 4, catalytic subunit Neighboring gene TLC domain containing 3B Neighboring gene RIKEN cDNA 4930451I11 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC107164, AC124505.11

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fructose binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fructose-bisphosphate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fructose-bisphosphate aldolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fructose-bisphosphate aldolase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables fructose-bisphosphate aldolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables fructose-bisphosphate aldolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fructose 1,6-bisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fructose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glycolytic process through fructose-6-phosphate IC
    Inferred by Curator
    more info
    PubMed 
    involved_in methylglyoxal biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle cell cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space HDA PubMed 
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm fibrous sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm head ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fructose-bisphosphate aldolase A
    Names
    muscle-type aldolase
    NP_001170778.1
    NP_001170779.1
    NP_031464.1
    XP_006507272.1
    XP_006507273.1
    XP_030097861.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177307.1NP_001170778.1  fructose-bisphosphate aldolase A isoform 1 precursor

      See identical proteins and their annotated locations for NP_001170778.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      BC089495, BY146617, CF617557, W64776
      Consensus CDS
      CCDS52399.1
      UniProtKB/TrEMBL
      A6ZI44, Q5FWB7
      Related
      ENSMUSP00000084846.5, ENSMUST00000087566.11
      Conserved Domains (1) summary
      pfam00274
      Location:69418
      Glycolytic; Fructose-bisphosphate aldolase class-I
    2. NM_001177308.1NP_001170779.1  fructose-bisphosphate aldolase A isoform 2

      See identical proteins and their annotated locations for NP_001170779.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in its 5' end and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      BC089495, BY785997, W64776
      Consensus CDS
      CCDS21845.1
      UniProtKB/Swiss-Prot
      P05064
      UniProtKB/TrEMBL
      Q5FWB7
      Related
      ENSMUSP00000101955.2, ENSMUST00000106348.8
      Conserved Domains (1) summary
      pfam00274
      Location:15364
      Glycolytic; Fructose-bisphosphate aldolase class-I
    3. NM_007438.4NP_031464.1  fructose-bisphosphate aldolase A isoform 2

      See identical proteins and their annotated locations for NP_031464.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      BC089495, CN694938, W64776
      Consensus CDS
      CCDS21845.1
      UniProtKB/Swiss-Prot
      P05064
      UniProtKB/TrEMBL
      Q5FWB7
      Related
      ENSMUSP00000032934.6, ENSMUST00000032934.12
      Conserved Domains (1) summary
      pfam00274
      Location:15364
      Glycolytic; Fructose-bisphosphate aldolase class-I

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126394406..126400166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242001.1XP_030097861.1  fructose-bisphosphate aldolase A isoform X2

      Conserved Domains (1) summary
      pfam00274
      Location:15364
      Glycolytic; Fructose-bisphosphate aldolase class-I
    2. XM_006507210.3XP_006507273.1  fructose-bisphosphate aldolase A isoform X2

      See identical proteins and their annotated locations for XP_006507273.1

      UniProtKB/Swiss-Prot
      P05064
      UniProtKB/TrEMBL
      Q5FWB7
      Conserved Domains (1) summary
      pfam00274
      Location:15364
      Glycolytic; Fructose-bisphosphate aldolase class-I
    3. XM_006507209.3XP_006507272.1  fructose-bisphosphate aldolase A isoform X1

      See identical proteins and their annotated locations for XP_006507272.1

      UniProtKB/TrEMBL
      A6ZI44
      Conserved Domains (1) summary
      pfam00274
      Location:69418
      Glycolytic; Fructose-bisphosphate aldolase class-I
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