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    Sirpa signal-regulatory protein alpha [ Mus musculus (house mouse) ]

    Gene ID: 19261, updated on 11-Jul-2021

    Summary

    Official Symbol
    Sirpaprovided by MGI
    Official Full Name
    signal-regulatory protein alphaprovided by MGI
    Primary source
    MGI:MGI:108563
    See related
    Ensembl:ENSMUSG00000037902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bi; P8; Pt; Bit; P84; SHP; SIRP; CD172; SHP-1; CD172a; Ptpns1; SHPS-1; Idd13.2; AI835480
    Expression
    Broad expression in cortex adult (RPKM 59.8), frontal lobe adult (RPKM 57.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sirpa in Genome Data Viewer
    Location:
    2 F1; 2 63.19 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (129432962..129474148)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (129591042..129632228)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (129418575..129457964)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F830045P16 gene Neighboring gene predicted gene 14040 Neighboring gene predicted gene 14041 Neighboring gene prodynorphin Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene 2_1620.1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cell-cell adhesion mediator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding involved in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphorylated amino acid binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in granulocyte migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monocyte extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within movement of cell or subcellular component IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of I-kappaB phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of chemokine (C-C motif) ligand 5 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cytokine production involved in inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of macrophage inflammatory protein 1 alpha production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phagocytosis, engulfment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within phagocytosis, recognition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type substrate 1
    Names
    CD172 antigen-like family member A
    SHP substrate 1
    brain Ig-like molecule with tyrosine-based activation motifs
    brain immunological-like with tyrosine-based motifs
    inhibitory receptor SHPS-1
    mSIRP-alpha1
    myD-1 antigen
    protein tyrosine phosphatase, non-receptor type substrate 1
    signal-regulatory protein alpha-1
    sirp-alpha-1
    NP_001171118.1
    NP_001277948.1
    NP_001277949.1
    NP_001277950.1
    NP_001277951.1
    NP_001342087.1
    NP_001342089.1
    NP_031573.2
    XP_006499049.1
    XP_017172053.1
    XP_017172057.1
    XP_017172058.1
    XP_030104595.1
    XP_030104598.1
    XP_030104600.1
    XP_036015585.1
    XP_036015587.1
    XP_036015588.1
    XP_036015589.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177647.2NP_001171118.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001171118.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (2) is shorter than isoform 3.
      Source sequence(s)
      AF072544, AK159617, BM899883, CD578948
      Consensus CDS
      CCDS50708.1
      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      A0A0R4J1Z7
      Related
      ENSMUSP00000125004.2, ENSMUST00000160276.2
      Conserved Domains (1) summary
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    2. NM_001291019.1NP_001277948.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001277948.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3). Both variants 4 and 5 encode isoform 3.
      Source sequence(s)
      AB018194, AK159617, BM899883, CD578948
      Consensus CDS
      CCDS71142.1
      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      E0CYM8
      Related
      ENSMUSP00000049022.8, ENSMUST00000049262.14
      Conserved Domains (4) summary
      cd00096
      Location:3538
      Ig; Ig strand A [structural motif]
      cd05772
      Location:148250
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:253348
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    3. NM_001291020.1NP_001277949.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001277949.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Both variants 4 and 5 encode isoform 3.
      Source sequence(s)
      AB018194, AK159617, BM899883
      Consensus CDS
      CCDS71142.1
      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      E0CYM8
      Related
      ENSMUSP00000124048.2, ENSMUST00000161620.8
      Conserved Domains (4) summary
      cd00096
      Location:3538
      Ig; Ig strand A [structural motif]
      cd05772
      Location:148250
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:253348
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    4. NM_001291021.1NP_001277950.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate in-frame exons in the central coding region, compared to variant 4, resulting in an isoform (4) that is shorter than isoform 3.
      Source sequence(s)
      AK159617, BM899883, CD578948, CX236057
      Consensus CDS
      CCDS71143.1
      UniProtKB/TrEMBL
      E9QPT7
      Related
      ENSMUSP00000096713.4, ENSMUST00000099113.10
      Conserved Domains (1) summary
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    5. NM_001291022.1NP_001277951.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 5 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 5' coding region and two in-frame exons in the central coding region, and also uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (5) is shorter than isoform 3.
      Source sequence(s)
      AK159617, BM899883, CD578948, CJ151068
      Consensus CDS
      CCDS79845.1
      UniProtKB/TrEMBL
      E0CX65
      Related
      ENSMUSP00000124888.2, ENSMUST00000163034.8
    6. NM_001355158.1NP_001342087.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS16729.1
      Related
      ENSMUSP00000137611.2, ENSMUST00000179001.8
      Conserved Domains (3) summary
      cd05772
      Location:148251
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:253356
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    7. NM_001355160.1NP_001342089.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL808126
      Conserved Domains (3) summary
      cd05772
      Location:136239
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:241344
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:23134
      Ig; Immunoglobulin domain
    8. NM_007547.4NP_031573.2  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_031573.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 4, resulting in an isoform (1) that is shorter than isoform 3. Variants 1 and 8 both encode the same isoform (1).
      Source sequence(s)
      AF072543, AK159617, BM899883, CD578948
      Consensus CDS
      CCDS16729.1
      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      Q6P6I8
      Related
      ENSMUSP00000099491.4, ENSMUST00000103202.10
      Conserved Domains (3) summary
      cd05772
      Location:148251
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:253356
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35146
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      129432962..129474148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316564.2XP_017172053.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      Conserved Domains (4) summary
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28139
      Ig; Immunoglobulin domain
    2. XM_036159695.1XP_036015588.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      Conserved Domains (4) summary
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28139
      Ig; Immunoglobulin domain
    3. XM_017316568.2XP_017172057.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X5

      UniProtKB/TrEMBL
      E9QPT7
      Conserved Domains (1) summary
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    4. XM_017316569.2XP_017172058.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X6

      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      A0A0R4J1Z7
      Conserved Domains (1) summary
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    5. XM_036159694.1XP_036015587.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      Conserved Domains (4) summary
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28139
      Ig; Immunoglobulin domain
    6. XM_036159692.1XP_036015585.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X3

      Conserved Domains (4) summary
      cd00096
      Location:3538
      Ig; Ig strand A [structural motif]
      cd05772
      Location:148250
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:253348
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    7. XM_006498986.4XP_006499049.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X3

      See identical proteins and their annotated locations for XP_006499049.1

      UniProtKB/TrEMBL
      E0CYM8
      Conserved Domains (4) summary
      cd00096
      Location:3538
      Ig; Ig strand A [structural motif]
      cd05772
      Location:148250
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:253348
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    8. XM_030248740.1XP_030104600.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X4

      Conserved Domains (3) summary
      cd05772
      Location:148251
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:253356
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    9. XM_030248735.2XP_030104595.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      Conserved Domains (4) summary
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28139
      Ig; Immunoglobulin domain
    10. XM_030248738.2XP_030104598.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      Conserved Domains (4) summary
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28139
      Ig; Immunoglobulin domain
    11. XM_036159696.1XP_036015589.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      Conserved Domains (4) summary
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28139
      Ig; Immunoglobulin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001177646.1: Suppressed sequence

      Description
      NM_001177646.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Support Center