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    Kcna5 potassium voltage-gated channel, shaker-related subfamily, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 16493, updated on 23-Jun-2021

    Summary

    Official Symbol
    Kcna5provided by MGI
    Official Full Name
    potassium voltage-gated channel, shaker-related subfamily, member 5provided by MGI
    Primary source
    MGI:MGI:96662
    See related
    Ensembl:ENSMUSG00000045534
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kv1.; Kv1.5
    Orthologs
    NEW
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    Genomic context

    See Kcna5 in Genome Data Viewer
    Location:
    6 F3; 6 61.35 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126509514..126512518, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126532551..126535555, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (126482569..126485573, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33276 Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene predicted gene, 38899 Neighboring gene predicted gene, 33320 Neighboring gene predicted gene, 33449

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25248

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables outward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables voltage-gated potassium channel activity involved in SA node cell action potential repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in atrial cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane hyperpolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane repolarization during SA node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane repolarization during atrial cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane repolarization during bundle of His cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of atrial cardiac muscle cell membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of membrane potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular canaliculus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily A member 5
    Names
    KV1-5
    voltage-gated potassium channel subunit Kv1.5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145983.2NP_666095.1  potassium voltage-gated channel subfamily A member 5

      See identical proteins and their annotated locations for NP_666095.1

      Status: VALIDATED

      Source sequence(s)
      AF108659, BC021787, CX240838
      Consensus CDS
      CCDS20554.1
      UniProtKB/Swiss-Prot
      Q61762
      Related
      ENSMUSP00000055673.4, ENSMUST00000060972.5
      Conserved Domains (4) summary
      smart00225
      Location:113207
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:305515
      Ion_trans; Ion transport protein
      pfam02214
      Location:113204
      BTB_2; BTB/POZ domain
      pfam07885
      Location:429506
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      126509514..126512518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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