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    Sirt3 sirtuin 3 [ Mus musculus (house mouse) ]

    Gene ID: 64384, updated on 17-Oct-2021

    Summary

    Official Symbol
    Sirt3provided by MGI
    Official Full Name
    sirtuin 3provided by MGI
    Primary source
    MGI:MGI:1927665
    See related
    Ensembl:ENSMUSG00000025486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sir2l3; AI848213; 2310003L23Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 35.3), liver adult (RPKM 33.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sirt3 in Genome Data Viewer
    Location:
    7; 7 F4- F5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140443576..140462222, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140863663..140882309, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (148049562..148068208, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene outer dense fiber of sperm tails 3 Neighboring gene Bet1 golgi vesicular membrane trafficking protein like Neighboring gene RIC8 guanine nucleotide exchange factor A Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene cytochrome c oxidase subunit 8B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NAD-dependent histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT enables NAD-dependent histone deacetylase activity (H3-K14 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent histone deacetylase activity (H3-K14 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent protein deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NAD-dependent protein deacetylase sirtuin-3
    Names
    NAD-dependent deacetylase sirtuin-3
    SIR2-like protein 3
    SIRT3L mitochondrial
    mSIR2L3
    mitochondrial protein lysine deacetylase
    regulatory protein SIR2 homolog 3
    silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3
    NP_001120823.1
    NP_001171275.1
    NP_071878.2
    XP_006536285.1
    XP_006536286.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127351.1NP_001120823.1  NAD-dependent protein deacetylase sirtuin-3 isoform 1

      See identical proteins and their annotated locations for NP_001120823.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional segment, resulting in a downstream AUG start codon, as compared to variant 3. The resulting isoform (1) is shorter at the N-terminus, as compared to isoform 2.
      Source sequence(s)
      AF299338, AF299339, BF681854, CT010402
      Consensus CDS
      CCDS21989.1
      UniProtKB/Swiss-Prot
      Q8R104
      UniProtKB/TrEMBL
      Q4FJK3
      Related
      ENSMUSP00000101663.4, ENSMUST00000106048.10
      Conserved Domains (1) summary
      cd01408
      Location:1231
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    2. NM_001177804.1NP_001171275.1  NAD-dependent protein deacetylase sirtuin-3 isoform 3

      See identical proteins and their annotated locations for NP_001171275.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longer isoform (2).
      Source sequence(s)
      AK075861, BF681854, CB953804
      UniProtKB/Swiss-Prot
      Q8R104
      Conserved Domains (1) summary
      cd01408
      Location:74308
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    3. NM_022433.2NP_071878.2  NAD-dependent protein deacetylase sirtuin-3 isoform 1

      See identical proteins and their annotated locations for NP_071878.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has an alternate 5' exon and an additional segment, resulting in a downstream AUG start codon, as compared to variant 3. The resulting isoform (1) is shorter at the N-terminus, as compared to isoform 2.
      Source sequence(s)
      AF299338, BF681854, CT010402
      Consensus CDS
      CCDS21989.1
      UniProtKB/Swiss-Prot
      Q8R104
      UniProtKB/TrEMBL
      Q4FJK3
      Related
      ENSMUSP00000026559.8, ENSMUST00000026559.14
      Conserved Domains (1) summary
      cd01408
      Location:1231
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140443576..140462222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006536222.5XP_006536285.1  NAD-dependent protein deacetylase sirtuin-3 isoform X1

      Conserved Domains (1) summary
      cl00195
      Location:74254
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    2. XM_006536223.5XP_006536286.1  NAD-dependent protein deacetylase sirtuin-3 isoform X2

      See identical proteins and their annotated locations for XP_006536286.1

      Related
      ENSMUSP00000114247.2, ENSMUST00000137024.8
      Conserved Domains (1) summary
      cl00195
      Location:1177
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
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