Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Scn1b sodium channel, voltage-gated, type I, beta [ Mus musculus (house mouse) ]

    Gene ID: 20266, updated on 23-Jun-2021

    Summary

    Official Symbol
    Scn1bprovided by MGI
    Official Full Name
    sodium channel, voltage-gated, type I, betaprovided by MGI
    Primary source
    MGI:MGI:98247
    See related
    Ensembl:ENSMUSG00000019194
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Biased expression in cerebellum adult (RPKM 317.2), cortex adult (RPKM 267.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Scn1b in Genome Data Viewer
    Location:
    7 B1; 7 19.3 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30815949..30826448, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (31116524..31127023, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (31901543..31911964, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118567482 Neighboring gene FXYD domain-containing ion transport regulator 3 Neighboring gene hepsin Neighboring gene GRAM domain containing 1A Neighboring gene predicted gene 10640

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle cell action potential involved in contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cardiac muscle cell action potential involved in contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within corticospinal neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within locomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane depolarization during Purkinje myocyte cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane depolarization during cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuronal action potential propagation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of atrial cardiac muscle cell membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of heart rate by cardiac conduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of sodium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of voltage-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to pyrethroid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in node of Ranvier IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with node of Ranvier ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of sodium channel complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of voltage-gated sodium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of voltage-gated sodium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium channel subunit beta-1
    Names
    sodium channel, voltage-gated, type I, beta polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011322.3NP_035452.1  sodium channel subunit beta-1 precursor

      See identical proteins and their annotated locations for NP_035452.1

      Status: VALIDATED

      Source sequence(s)
      AC158993, CD363348, CD776697, U46681
      Consensus CDS
      CCDS21126.1
      UniProtKB/Swiss-Prot
      P97952
      Related
      ENSMUSP00000096148.5, ENSMUST00000098548.8
      Conserved Domains (1) summary
      pfam07686
      Location:23147
      V-set; Immunoglobulin V-set domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30815949..30826448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242258.2XP_030098118.1  sodium channel subunit beta-1 isoform X1

      Conserved Domains (1) summary
      pfam07686
      Location:8114
      V-set; Immunoglobulin V-set domain
    Support Center