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    Idh1 isocitrate dehydrogenase 1 (NADP+), soluble [ Mus musculus (house mouse) ]

    Gene ID: 15926, updated on 5-Jul-2021

    Summary

    Official Symbol
    Idh1provided by MGI
    Official Full Name
    isocitrate dehydrogenase 1 (NADP+), solubleprovided by MGI
    Primary source
    MGI:MGI:96413
    See related
    Ensembl:ENSMUSG00000025950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ID; Id-; Id-1; Idh-; Idpc; Idh-1; AI314845; AI788952; E030024J03Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 104.0), CNS E18 (RPKM 83.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Idh1 in Genome Data Viewer
    Location:
    1 C2- C3; 1 32.91 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65197775..65225638, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65158616..65186479, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (65205190..65233053, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D630023F18 gene Neighboring gene crystallin, gamma A Neighboring gene predicted gene, 36358 Neighboring gene phosphoinositide kinase, FYVE type zinc finger containing Neighboring gene parathyroid hormone 2 receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC115782

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables isocitrate dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables isocitrate dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables isocitrate dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables isocitrate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    isocitrate dehydrogenase [NADP] cytoplasmic
    Names
    IDH
    IDP
    NADP(+)-specific ICDH
    cytosolic NADP-isocitrate dehydrogenase
    oxalosuccinate decarboxylase
    NP_001104790.1
    NP_034627.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111320.1NP_001104790.1  isocitrate dehydrogenase [NADP] cytoplasmic

      See identical proteins and their annotated locations for NP_001104790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK167158, BY787507, CF379827, CF950262
      Consensus CDS
      CCDS15016.1
      UniProtKB/Swiss-Prot
      O88844
      Related
      ENSMUSP00000127307.2, ENSMUST00000169032.8
      Conserved Domains (1) summary
      PTZ00435
      Location:1411
      PTZ00435; isocitrate dehydrogenase; Provisional
    2. NM_010497.3NP_034627.3  isocitrate dehydrogenase [NADP] cytoplasmic

      See identical proteins and their annotated locations for NP_034627.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK167158, BB868400, CF379827
      Consensus CDS
      CCDS15016.1
      UniProtKB/Swiss-Prot
      O88844
      Related
      ENSMUSP00000095316.5, ENSMUST00000097709.11
      Conserved Domains (1) summary
      PTZ00435
      Location:1411
      PTZ00435; isocitrate dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      65197775..65225638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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