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    Napb N-ethylmaleimide sensitive fusion protein attachment protein beta [ Mus musculus (house mouse) ]

    Gene ID: 17957, updated on 5-Sep-2021

    Summary

    Official Symbol
    Napbprovided by MGI
    Official Full Name
    N-ethylmaleimide sensitive fusion protein attachment protein betaprovided by MGI
    Primary source
    MGI:MGI:104562
    See related
    Ensembl:ENSMUSG00000027438
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; I4; b-; Brp; I47; E161; Brp14; SNARE; b-SNAP
    Expression
    Biased expression in frontal lobe adult (RPKM 69.4), cortex adult (RPKM 55.9) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Napb in Genome Data Viewer
    Location:
    2; 2 G3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (148535905..148574396, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (148693985..148732425, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (148520393..148558156, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene NTF2-related export protein 1 Neighboring gene predicted gene, 46771 Neighboring gene GDNF-inducible zinc finger protein 1 Neighboring gene uncharacterized LOC108168731 Neighboring gene predicted gene, 54122 Neighboring gene cystatin-like 1 Neighboring gene cystatin 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables soluble NSF attachment protein activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables syntaxin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in SNARE complex disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within SNARE complex disassembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of synaptic vesicle priming IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic vesicle priming IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within regulation of synaptic vesicle priming IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of synaptic vesicle priming IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic vesicle priming IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within synaptic transmission, glutamatergic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in glutamatergic synapse IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myelin sheath HDA PubMed 
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    beta-soluble NSF attachment protein
    Names
    N-ethylmaleimide-sensitive factor attachment protein beta
    SNAP-beta
    brain protein 14
    brain protein I47

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019632.3NP_062606.1  beta-soluble NSF attachment protein

      See identical proteins and their annotated locations for NP_062606.1

      Status: PROVISIONAL

      Source sequence(s)
      AL844519, AL928638
      Consensus CDS
      CCDS16842.1
      UniProtKB/Swiss-Prot
      P28663
      Related
      ENSMUSP00000028926.7, ENSMUST00000028926.13
      Conserved Domains (1) summary
      cd15832
      Location:9287
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      148535905..148574396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248234.1XP_030104094.1  beta-soluble NSF attachment protein isoform X1

      Conserved Domains (1) summary
      pfam14938
      Location:34210
      SNAP; Soluble NSF attachment protein, SNAP

    RNA

    1. XR_004938799.1 RNA Sequence

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