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    Gpsm1 G-protein signalling modulator 1 (AGS3-like, C. elegans) [ Mus musculus (house mouse) ]

    Gene ID: 67839, updated on 11-Jul-2021

    Summary

    Official Symbol
    Gpsm1provided by MGI
    Official Full Name
    G-protein signalling modulator 1 (AGS3-like, C. elegans)provided by MGI
    Primary source
    MGI:MGI:1915089
    See related
    Ensembl:ENSMUSG00000026930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ag; Ags3; AW107933; 1810037C22Rik
    Expression
    Broad expression in ovary adult (RPKM 24.9), whole brain E14.5 (RPKM 24.0) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gpsm1 in Genome Data Viewer
    Location:
    2; 2 A3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26204623..26238249)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26314611..26348237)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (26171060..26203755)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52504 Neighboring gene coiled-coil domain containing 187 Neighboring gene predicted gene, 35807 Neighboring gene predicted gene, 52505 Neighboring gene predicted gene 13562 Neighboring gene DNL-type zinc finger Neighboring gene caspase recruitment domain family, member 9 Neighboring gene small nuclear RNA activating complex, polypeptide 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GDP-dissociation inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    G-protein-signaling modulator 1
    Names
    activator of G-protein signaling 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199146.1NP_001186075.1  G-protein-signaling modulator 1 isoform 2

      See identical proteins and their annotated locations for NP_001186075.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' terminus which results in the use of an alternate tranlation initiation site and lacks an in-frame exon at the 3' end, compared to variant 3. Variant 2 encodes isoform 2 which has a shorter and distinct N-terminus, compared to isoform 3.
      Source sequence(s)
      AK084631, BC071197, CA317518
      Consensus CDS
      CCDS57158.1
      UniProtKB/Swiss-Prot
      Q6IR34
      Related
      ENSMUSP00000077686.6, ENSMUST00000078616.12
      Conserved Domains (6) summary
      smart00390
      Location:534556
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      sd00006
      Location:207234
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:106138
      TPR_1; Tetratricopeptide repeat
      pfam02188
      Location:434455
      GoLoco; GoLoco motif
      pfam13176
      Location:288322
      TPR_7; Tetratricopeptide repeat
      pfam13424
      Location:207278
      TPR_12; Tetratricopeptide repeat
    2. NM_001199147.1NP_001186076.1  G-protein-signaling modulator 1 isoform 3

      See identical proteins and their annotated locations for NP_001186076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      BC071197, CK618701
      Consensus CDS
      CCDS57159.1
      UniProtKB/Swiss-Prot
      Q6IR34
      Related
      ENSMUSP00000067964.7, ENSMUST00000066889.13
      Conserved Domains (6) summary
      smart00390
      Location:626648
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      sd00006
      Location:239266
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:138170
      TPR_1; Tetratricopeptide repeat
      pfam02188
      Location:526547
      GoLoco; GoLoco motif
      pfam13176
      Location:320354
      TPR_7; Tetratricopeptide repeat
      pfam13424
      Location:239310
      TPR_12; Tetratricopeptide repeat
    3. NM_001355574.1NP_001342503.1  G-protein-signaling modulator 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL732541
      Conserved Domains (5) summary
      smart00390
      Location:571593
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      COG0457
      Location:37335
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:184211
      TPR; TPR repeat [structural motif]
      pfam02188
      Location:471492
      GoLoco; GoLoco motif
      pfam13424
      Location:184255
      TPR_12; Tetratricopeptide repeat
    4. NM_001355575.1NP_001342504.1  G-protein-signaling modulator 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and uses an alternate splice junction compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL732541
      Related
      ENSMUSP00000115680.2, ENSMUST00000145884.8
      Conserved Domains (4) summary
      COG0457
      Location:66237
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:86113
      TPR; TPR repeat [structural motif]
      pfam02188
      Location:373394
      GoLoco; GoLoco motif
      pfam13424
      Location:86157
      TPR_12; Tetratricopeptide repeat
    5. NM_001355576.1NP_001342505.1  G-protein-signaling modulator 1 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL732541
      Conserved Domains (5) summary
      smart00390
      Location:511533
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      COG0457
      Location:27335
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:184211
      TPR; TPR repeat [structural motif]
      pfam02188
      Location:411432
      GoLoco; GoLoco motif
      pfam13424
      Location:184255
      TPR_12; Tetratricopeptide repeat
    6. NM_153410.5NP_700459.2  G-protein-signaling modulator 1 isoform 1

      See identical proteins and their annotated locations for NP_700459.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has an alternate 5' terminus which results in the use of an alternate tranlation initiation site, compared to variant 3. Variant 1 encodes isoform 1 which has a shorter and distinct N-terminus, compared to isoform 3.
      Source sequence(s)
      AK048691, BC071197, CA317518
      Consensus CDS
      CCDS15800.1
      UniProtKB/Swiss-Prot
      Q6IR34
      Related
      ENSMUSP00000065000.3, ENSMUST00000066936.9
      Conserved Domains (6) summary
      smart00390
      Location:594616
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      sd00006
      Location:207234
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:106138
      TPR_1; Tetratricopeptide repeat
      pfam02188
      Location:494515
      GoLoco; GoLoco motif
      pfam13176
      Location:288322
      TPR_7; Tetratricopeptide repeat
      pfam13424
      Location:207278
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      26204623..26238249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162509.1XP_036018402.1  G-protein-signaling modulator 1 isoform X2

      Related
      ENSMUSP00000109769.3, ENSMUST00000114134.9
      Conserved Domains (1) summary
      pfam02188
      Location:5776
      GoLoco; GoLoco motif
    2. XM_036162508.1XP_036018401.1  G-protein-signaling modulator 1 isoform X1

      Conserved Domains (1) summary
      pfam02188
      Location:117136
      GoLoco; GoLoco motif
    3. XM_006498255.3XP_006498318.1  G-protein-signaling modulator 1 isoform X3

      Conserved Domains (1) summary
      pfam02188
      Location:4160
      GoLoco; GoLoco motif

    RNA

    1. XR_003953699.2 RNA Sequence

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