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    Fam81a family with sequence similarity 81, member A [ Mus musculus (house mouse) ]

    Gene ID: 76886, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fam81aprovided by MGI
    Official Full Name
    family with sequence similarity 81, member Aprovided by MGI
    Primary source
    MGI:MGI:1924136
    See related
    Ensembl:ENSMUSG00000032224 AllianceGenome:MGI:1924136
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6430514L14Rik
    Summary
    Is expressed in brain; jaw bone; nasal epithelium; trigeminal ganglion; and vibrissa. Orthologous to human FAM81A (family with sequence similarity 81 member A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 31.1), frontal lobe adult (RPKM 29.8) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam81a in Genome Data Viewer
    Location:
    9 D; 9 39.27 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (69996586..70049840, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (70089304..70142558, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24529 Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene STARR-seq mESC enhancer starr_24532 Neighboring gene STARR-seq mESC enhancer starr_24534 Neighboring gene predicted gene, 39369 Neighboring gene predicted gene, 39476 Neighboring gene predicted gene, 24257 Neighboring gene STARR-positive B cell enhancer ABC_E1389 Neighboring gene predicted gene, 26849 Neighboring gene STARR-positive B cell enhancer ABC_E5083 Neighboring gene myosin IE

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased Connexin36 Phosphorylation in AII Amacrine Cell Coupling of the Mouse Myopic Retina. Banerjee S, et al. Front Cell Neurosci, 2020. PMID 32547367, Free PMC Article
    2. Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Ling KH, et al. Genome Biol, 2009. PMID 19799774, Free PMC Article
    3. Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Li J, et al. Sci Signal, 2016 Aug 9. PMID 27507650
    4. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article
    5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM81A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029784.2 → NP_084060.1  protein FAM81A

      See identical proteins and their annotated locations for NP_084060.1

      Status: PROVISIONAL

      Source sequence(s)
      AC157950
      Consensus CDS
      CCDS40679.1
      UniProtKB/Swiss-Prot
      Q3UXZ6, Q8BQV1, Q8C548, Q8R3B5, Q9D369
      Related
      ENSMUSP00000034749.9, ENSMUST00000034749.16
      Conserved Domains (1) summary
      COG1196
      Location:76 → 317
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      69996586..70049840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244712.1 → XP_030100572.1  protein FAM81A isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:68 → 309
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_006511551.4 → XP_006511614.1  protein FAM81A isoform X1

      See identical proteins and their annotated locations for XP_006511614.1

      UniProtKB/Swiss-Prot
      Q3UXZ6, Q8BQV1, Q8C548, Q8R3B5, Q9D369
      Conserved Domains (1) summary
      COG1196
      Location:76 → 317
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_006511550.5 → XP_006511613.1  protein FAM81A isoform X1

      See identical proteins and their annotated locations for XP_006511613.1

      UniProtKB/Swiss-Prot
      Q3UXZ6, Q8BQV1, Q8C548, Q8R3B5, Q9D369
      Conserved Domains (1) summary
      COG1196
      Location:76 → 317
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UXZ6.2 GenPept UniProtKB/Swiss-Prot:Q3UXZ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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